Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele

Peter Van Der Riet, Debra Karp, Evan Farmer, Qingyi Wei, Lawrence Grossman, Kaori Tokino, J. Michael Ruppert, David Sidransky

Research output: Contribution to journalArticle

Abstract

Basal cell carcinoma (BCC) of the skin represents a unique group of tumors strongly associated with exposure to UV light. Unlike squamous carcinoma of the skin, BCC is generally indolent, noninvasive, and rarely metastatic. To study the involvenment of tumor suppressor genes in these neoplasms, we analyzed 36 BCCs for p53 mutations and a subset of these tumors for loss of chromosomes 17p and 9q. Sixty-nine % of sporadic BCCs had lost a 9q allele, with the common are of loss surrounding the putative gene for nevoid BCC or Gorlin's syndrome. Forty-four % (16 of 36) of BCCs had a mutated p53 allele, usually opposite pyrimidine tracts, which is consistent with UV-induced mutations. Surprisingly, only one tumor had lost a 17p allele, and in all BCCs only one p53 allele was inactivated. This is in direct contrast to other epithelial tumors, which usually progress by the inactivation of both p53 alleles.

Original languageEnglish (US)
Pages (from-to)25-27
Number of pages3
JournalCancer Research
Volume54
Issue number1
StatePublished - Jan 1 1994

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Basal Cell Carcinoma
Chromosomes
Alleles
Basal Cell Nevus Syndrome
Neoplasms
Skin
Mutation
Ultraviolet Rays
Tumor Suppressor Genes
Squamous Cell Carcinoma
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Van Der Riet, P., Karp, D., Farmer, E., Wei, Q., Grossman, L., Tokino, K., ... Sidransky, D. (1994). Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele. Cancer Research, 54(1), 25-27.

Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele. / Van Der Riet, Peter; Karp, Debra; Farmer, Evan; Wei, Qingyi; Grossman, Lawrence; Tokino, Kaori; Ruppert, J. Michael; Sidransky, David.

In: Cancer Research, Vol. 54, No. 1, 01.01.1994, p. 25-27.

Research output: Contribution to journalArticle

Van Der Riet, P, Karp, D, Farmer, E, Wei, Q, Grossman, L, Tokino, K, Ruppert, JM & Sidransky, D 1994, 'Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele', Cancer Research, vol. 54, no. 1, pp. 25-27.
Van Der Riet P, Karp D, Farmer E, Wei Q, Grossman L, Tokino K et al. Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele. Cancer Research. 1994 Jan 1;54(1):25-27.
Van Der Riet, Peter ; Karp, Debra ; Farmer, Evan ; Wei, Qingyi ; Grossman, Lawrence ; Tokino, Kaori ; Ruppert, J. Michael ; Sidransky, David. / Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele. In: Cancer Research. 1994 ; Vol. 54, No. 1. pp. 25-27.
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