Progression of Basal Cell Carcinoma through Loss of Chromosome 9q and Inactivation of a Single p53 Allele

Peter van der Riet, Debra Karp, Evan Farmer, Qingyi Wei, Lawrence Grossman, Kaon Tokino, J. Michael Ruppert, David Sidransky

Research output: Contribution to journalArticlepeer-review

Abstract

Basal cell carcinoma (BCC) of the skin represents a unique group of tumors strongly associated with exposure to UV light. Unlike squamous carcinoma of the skin, BCC is generally indolent, noninvasive, and rarely metastatic. To study the involvement of tumor suppressor genes in these neoplasms, we analyzed 36 BCCs for p53 mutations and a subset of these tumors for loss of chromosomes 17p and 9q. Sixty-nine % of sporadic BCCs had lost a 9q allele, with the common area of loss surrounding the putative gene for nevoid BCC or Gorlin's syndrome. Forty-four % (16 of 36) of BCCs had a mutated p53 allele, usually opposite pyrimidine tracts, which is consistent with UV-induced mutations. Surprisingly, only one tumor had lost a 17p allele, and in all BCCs only one p53 allele was inactivated. This is in direct contrast to other epithelial tumors, which usually progress by the inactivation of both p53 alleles.

Original languageEnglish (US)
Pages (from-to)25-27
Number of pages3
JournalCancer Research
Volume54
Issue number1
StatePublished - Jan 1994

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Progression of Basal Cell Carcinoma through Loss of Chromosome 9q and Inactivation of a Single p53 Allele'. Together they form a unique fingerprint.

Cite this