Progression of active trachoma to scarring in a cohort of Tanzanian children

S. K. West, B. Muñoz, H. Mkocha, Y. H. Hsieh, M. C. Lynch

Research output: Contribution to journalArticlepeer-review

Abstract

Risk factors for the incidence of scarring are needed to inform trachoma control programs in countries hyperendemic for this blinding disease. A cohort of pre-school children with constant, severe trachoma, and an age, sex, and neighborhood matched cohort of children without constant severe trachoma were followed for seven years to determine the incidence of scarring. The incidence of scarring in the children with constant severe trachoma was 29.2% versus 9.6% in the comparison group. In a model adjusting for multiple factors, significant predictors of scarring were increasing age, female, and constant severe trachoma (OR = 4.85, 95% CL = 2.05, 11.40). Infection with C. trachomatis at follow up was also associated with scarring in both groups of children. It is likely that these children have a different host response to infection, and represent a subgroup at high risk for the blinding complications of trachoma. Reducing exposure to infection in the community through antibiotics and changes in hygiene practices is still the most promising control strategy.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalOphthalmic Epidemiology
Volume8
Issue number2-3
DOIs
StatePublished - 2001

Keywords

  • Blindness
  • Children
  • Chlamydia infection
  • Conjunctival scarring
  • Face washing
  • Longitudinal study
  • Risk factors
  • Tanzania
  • Trachoma
  • Trichiasis

ASJC Scopus subject areas

  • Epidemiology
  • Ophthalmology

Fingerprint

Dive into the research topics of 'Progression of active trachoma to scarring in a cohort of Tanzanian children'. Together they form a unique fingerprint.

Cite this