Abstract
Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.
Original language | English (US) |
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Pages (from-to) | 439-449 |
Number of pages | 11 |
Journal | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Volume | 11 |
DOIs | |
State | Published - Dec 2019 |
Keywords
- Cytoarchitecture
- Hippocampus
- Histology
- Human
- Neuroanatomy
- Neuroimaging
- Structural imaging
- Volumetry
- ex vivo
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health