Progress update from the hippocampal subfields group

Hippocampal Subfields Group

Research output: Contribution to journalArticle

Abstract

Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

Original languageEnglish (US)
Pages (from-to)439-449
Number of pages11
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 1 2019

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Temporal Lobe
Joint Diseases
Research
Reproducibility of Results
Magnetic Resonance Imaging

Keywords

  • Cytoarchitecture
  • ex vivo
  • Hippocampus
  • Histology
  • Human
  • Neuroanatomy
  • Neuroimaging
  • Structural imaging
  • Volumetry

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Progress update from the hippocampal subfields group. / Hippocampal Subfields Group.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 11, 01.12.2019, p. 439-449.

Research output: Contribution to journalArticle

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abstract = "Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.",
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AU - Amaral, Robert S.C.

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AU - Augustinack, Jean C.

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AU - Burggren, Alison C.

AU - Chakravarty, M. Mallar

AU - Chételat, Gaël

AU - de Flores, Robin

AU - DeKraker, Jordan

AU - Ding, Song Lin

AU - Geerlings, Mirjam I.

AU - Huang, Yushan

AU - Insausti, Ricardo

AU - Johnson, Elliott G.

AU - Kanel, Prabesh

AU - Kedo, Olga

AU - Kennedy, Kristen M.

AU - Keresztes, Attila

AU - Lee, Joshua K.

AU - Lindenberger, Ulman

AU - Mueller, Susanne G.

AU - Mulligan, Elizabeth M.

AU - Ofen, Noa

AU - Palombo, Daniela J.

AU - Pasquini, Lorenzo

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AU - Raz, Naftali

AU - Rodrigue, Karen M.

AU - Schlichting, Margaret L.

AU - Lee Shing, Yee

AU - Stark, Craig E.L.

AU - Steve, Trevor A.

AU - Suthana, Nanthia A.

AU - Wang, Lei

AU - Werkle-Bergner, Markus

AU - Yushkevich, Paul A.

AU - Yu, Qijing

AU - Wisse, Laura E.M.

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KW - Neuroanatomy

KW - Neuroimaging

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KW - Volumetry

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