Progress update from the hippocampal subfields group

Hippocampal Subfields Group

Research output: Contribution to journalArticle

Abstract

Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

Original languageEnglish (US)
Pages (from-to)439-449
Number of pages11
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
StatePublished - Dec 2019

Keywords

  • Cytoarchitecture
  • Hippocampus
  • Histology
  • Human
  • Neuroanatomy
  • Neuroimaging
  • Structural imaging
  • Volumetry
  • ex vivo

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Progress update from the hippocampal subfields group'. Together they form a unique fingerprint.

  • Cite this