Progress toward HIV eradication: Case reports, current efforts, and the challenges associated with cure

Alyssa R. Martin, Robert F. Siliciano

Research output: Contribution to journalArticlepeer-review

Abstract

An estimated 35 million people worldwide are infected with HIV, yet a widely applicable cure strategy remains elusive. Recent case reports have suggested that curing HIV infection is possible, renewing excitement about research efforts. We describe those cases and discuss their relevance to the global HIV epidemic. We also review ongoing cure strategies that are transitioning from the lab to the clinic, and the assays and clinical assessments that can be used to evaluate cure interventions.

Original languageEnglish (US)
Pages (from-to)215-228
Number of pages14
JournalAnnual review of medicine
Volume67
DOIs
StatePublished - Jan 14 2016

Keywords

  • Early treatment
  • Genome editing
  • HIV-1
  • Persistence
  • Shock and kill
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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