Progress in the rational design of an AIDS vaccine

Gary J. Nabel, Peter D. Kwong, John R. Mascola

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus-1 (HIV-1) has a high degree of genetic and antigenic diversity that has impeded the development of an effective vaccine using traditional methods. We are attempting to develop an AIDS vaccine by employing strategies that include structural biology and computational modelling, in an effort to develop immunogens capable of eliciting neutralizing antibodies of the requisite breadth and potency against circulating strains of HIV-1.

Original languageEnglish (US)
Pages (from-to)2759-2765
Number of pages7
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume366
Issue number1579
DOIs
StatePublished - Oct 12 2011
Externally publishedYes

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Keywords

  • Antibody response
  • Computational techniques
  • HIV-1
  • Informatics
  • Structural biology
  • Vaccine design

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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