Progress in the discovery and development of glutamate carboxypeptidase II inhibitors

Research output: Contribution to journalReview articlepeer-review

Abstract

During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from preclinical and clinical studies.

Original languageEnglish (US)
Pages (from-to)767-776
Number of pages10
JournalDrug Discovery Today
Volume12
Issue number17-18
DOIs
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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