Progress in the discovery and development of glutamate carboxypeptidase II inhibitors

Takashi Tsukamoto; Krystyna M. Wozniak; Barbara S. Slusher

doi:10.1016/j.drudis.2007.07.010

Progress in the discovery and development of glutamate carboxypeptidase II inhibitors

Takashi Tsukamoto, Krystyna M. Wozniak, Barbara S. Slusher

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from preclinical and clinical studies.

Original language	English (US)
Pages (from-to)	767-776
Number of pages	10
Journal	Drug Discovery Today
Volume	12
Issue number	17-18
DOIs	https://doi.org/10.1016/j.drudis.2007.07.010
State	Published - Sep 2007
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.drudis.2007.07.010

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title = "Progress in the discovery and development of glutamate carboxypeptidase II inhibitors",

abstract = "During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from preclinical and clinical studies.",

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AU - Wozniak, Krystyna M.

AU - Slusher, Barbara S.

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AB - During the past 10 years, substantial progress has been made in the discovery and development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These inhibitors have provided the necessary tools to investigate the physiological role of GCP II as well as the potential therapeutic benefits of its inhibition in neurological disorders of glutamatergic dysregulation. This review article details key GCP II inhibitors discovered in the last decade and important findings from preclinical and clinical studies.

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Progress in the discovery and development of glutamate carboxypeptidase II inhibitors

Abstract

ASJC Scopus subject areas

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