TY - JOUR
T1 - Progress and barriers for the control of diarrhoeal disease
AU - Santosham, Mathuram
AU - Chandran, Aruna
AU - Fitzwater, Sean
AU - Fischer-Walker, Christa
AU - Baqui, Abdullah H.
AU - Black, Robert
PY - 2010
Y1 - 2010
N2 - Discovery of intestinal sodium-glucose transport was the basis for development of oral rehydration solution, and was hailed as potentially the most important medical advance of the 20th century. Before widespread use of oral rehydration solution, treatment for diarrhoea was restricted to intravenous fluid replacement, for which patients had to go to a health-care facility to access appropriate equipment. These facilities were usually neither available nor reasonable to use in the resource-poor settings most affected by diarrhoea. Use of oral rehydration solution has stagnated, despite being effective, inexpensive, and widely available. Thus, diarrhoea continues to be a leading cause of child death with consistent mortality rates during the past 5 years. New methods for prevention, management, and treatment of diarrhoea-including an improved oral rehydration formulation, zinc supplementation, and rotavirus vaccines-make now the time to revitalise efforts to reduce diarrhoea mortality worldwide.
AB - Discovery of intestinal sodium-glucose transport was the basis for development of oral rehydration solution, and was hailed as potentially the most important medical advance of the 20th century. Before widespread use of oral rehydration solution, treatment for diarrhoea was restricted to intravenous fluid replacement, for which patients had to go to a health-care facility to access appropriate equipment. These facilities were usually neither available nor reasonable to use in the resource-poor settings most affected by diarrhoea. Use of oral rehydration solution has stagnated, despite being effective, inexpensive, and widely available. Thus, diarrhoea continues to be a leading cause of child death with consistent mortality rates during the past 5 years. New methods for prevention, management, and treatment of diarrhoea-including an improved oral rehydration formulation, zinc supplementation, and rotavirus vaccines-make now the time to revitalise efforts to reduce diarrhoea mortality worldwide.
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U2 - 10.1016/S0140-6736(10)60356-X
DO - 10.1016/S0140-6736(10)60356-X
M3 - Review article
C2 - 20609988
AN - SCOPUS:77954703375
SN - 0140-6736
VL - 376
SP - 63
EP - 67
JO - The Lancet
JF - The Lancet
IS - 9734
ER -