Programming events in the regulation of cell proliferation and death

R. Berges, J. T. Isaacs

Research output: Contribution to journalArticlepeer-review

Abstract

In developing new and more successful therapies for preventing and treating cancer, it is critical to understand what normally regulates cell proliferation and cell death and what are the specific dysfunctions associated with these regulations in individual cancers. Here we review the programmed series of molecular, cellular, and biochemical events required for a cell's entrance and progression through the proliferative vs death processes as a starting point for such approaches to new therapies.

Original languageEnglish (US)
Pages (from-to)356-361
Number of pages6
JournalClinical chemistry
Volume39
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • apoptosis
  • cancer
  • cyclins
  • p34 kinase

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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