Prognostic value of T lymphocyte subset ratios for renal transplant survival in patients on different immunosuppressive regimens

F. C. Henny, A. van Es, P. J. Oljans, W. M. Baldwin, H. J. Tanke, L. C. Paul

Research output: Contribution to journalArticle

Abstract

Previously we reported that the pre-treatment and pre-injection OKT4/OKT8 ratio can be used to predict renal allograft survival. Patients on azathioprine (Aza) and low-dose steroids (St) with a pretransplant ratio ≤ 1.6 exhibited a 6-month grafts survival of 33% compared with 79% for those with ratio > 1.6 (P = 0.02). Furthermore, 100% of the rejection episodes treated with high doses of prednisone in patients with a prerejection ratio ≤ 1.6 were irreversible in comparison with only 10% for patients with a ratio > 1.6 (P <0.001). In the present study, we investigated the prognostic value of the OKT4/OKT8 ratio for patients who received rabbit antithymocyte globulin (RATG) as anti-rejection therapy or cyclosporin A (CsA) as basic immunosuppressive therapy. No correlation was found between the pre-transplant OKT4/OKT8 ratio and 6-month graft survival for either treatment group because of an improved graft survival among patients with a pre-transplant ratio ≤ 1.6 (78% for patients who received RATG and 85% for CsA-treated patients). For Aza-treated patients with an OKT4/OKT8 ratio ≤ 1.6 at the time of rejection, rejection episodes that were treated with RATG were reversible in 78% of the cases, whereas among CsA-treated patients rejection epidoses treated with high doses of prednisone were reversible in 72% of the cases. No significant differences in graft survival or reversibility of rejection episodes between patients with a pre-transplant or pre-rejection of OKT4/OKT8 ratio > 1.6 were found. Furthermore, in both the CsA and the Aza-treated patients (with or without RATG), the OKT4/OKT8 ratio had decreased significantly 3 months after transplantation. This decrease was associated with cytomegalovirus infections rather than the type of immunosuppressive therapy.

Original languageEnglish (US)
Pages (from-to)373-380
Number of pages8
JournalClinical and Experimental Immunology
Volume65
Issue number2
StatePublished - 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

Cite this

Henny, F. C., van Es, A., Oljans, P. J., Baldwin, W. M., Tanke, H. J., & Paul, L. C. (1986). Prognostic value of T lymphocyte subset ratios for renal transplant survival in patients on different immunosuppressive regimens. Clinical and Experimental Immunology, 65(2), 373-380.