Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome

Marc Dewey; Carlos E. Rochitte; Mohammad R. Ostovaneh; Marcus Y. Chen; Richard T. George; Hiroyuki Niinuma; Kakuya Kitagawa; Roger Laham; Klaus Kofoed; Cesar Nomura; Hajime Sakuma; Kunihiro Yoshioka; Vishal C. Mehra; Masahiro Jinzaki; Sachio Kuribayashi; Michael Laule; Narinder Paul; Arthur J. Scholte; Rodrigo Cerci; John Hoe; Swee Yaw Tan; Frank J. Rybicki; Matthew B. Matheson; Andrea L. Vavere; Andrew E. Arai; Julie M. Miller; Christopher Cox; Jeffrey Brinker; Melvin E. Clouse; Marcelo Di Carli; João A.C. Lima; Armin Arbab-Zadeh

doi:10.1016/j.jcct.2021.04.005

Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome

Marc Dewey, Carlos E. Rochitte, Mohammad R. Ostovaneh, Marcus Y. Chen, Richard T. George, Hiroyuki Niinuma, Kakuya Kitagawa, Roger Laham, Klaus Kofoed, Cesar Nomura, Hajime Sakuma, Kunihiro Yoshioka, Vishal C. Mehra, Masahiro Jinzaki, Sachio Kuribayashi, Michael Laule, Narinder Paul, Arthur J. Scholte, Rodrigo Cerci, John HoeSwee Yaw Tan, Frank J. Rybicki, Matthew B. Matheson, Andrea L. Vavere, Andrew E. Arai, Julie M. Miller, Christopher Cox, Jeffrey Brinker, Melvin E. Clouse, Marcelo Di Carli, João A.C. Lima, Armin Arbab-Zadeh

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnormal) was assessed by 5-year major cardiovascular events (MACE) free survival and area under the receiver-operating-characteristic curve (AUC). Results: Follow up beyond 2-years was available in 323 patients. MACE-free survival rate was greater among patients with normal combined CTA-CTP findings compared to ICA-SPECT: 85 vs. 80% (95% confidence interval [CI] for difference 0.1, 11.3) though event-free survival time was similar (4.54 vs. 4.37 years, 95% CI for difference: -0.03, 0.36). Abnormal results by combined CTA-CTP was associated with 3.83 years event-free survival vs. 3.66 years after abnormal combined ICA-SPECT (95% CI for difference: -0.05, 0.39). Predicting MACE by AUC also was similar: 65 vs. 65 (difference 0.1; 95% CI -4.6, 4.9). When MACE was restricted to cardiovascular death, myocardial infarction, or stroke, AUC for CTA-CTP was 71 vs. 60 by ICA-SPECT (difference 11.2; 95% CI -1.0, 19.7). Conclusions: Combined CTA-CTP evaluation yields at least equal 5-year prognostic information as combined ICA-SPECT assessment in patients presenting with suspected coronary artery disease. Noninvasive cardiac CT assessment may eliminate the need for diagnostic cardiac catheterization in many patients. Clinical trial registration: NCT00934037.

Original language	English (US)
Pages (from-to)	485-491
Number of pages	7
Journal	Journal of cardiovascular computed tomography
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.jcct.2021.04.005
State	Published - Nov 1 2021
Externally published	Yes

Keywords

CT angiography
Coronary artery disease
Coronary atherosclerosis
Coronary heart disease
Coronary imaging
Myocardial perfusion imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.jcct.2021.04.005

Fingerprint

Dive into the research topics of 'Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome'. Together they form a unique fingerprint.

Cite this

Dewey, M., Rochitte, C. E., Ostovaneh, M. R., Chen, M. Y., George, R. T., Niinuma, H., Kitagawa, K., Laham, R., Kofoed, K., Nomura, C., Sakuma, H., Yoshioka, K., Mehra, V. C., Jinzaki, M., Kuribayashi, S., Laule, M., Paul, N., Scholte, A. J., Cerci, R., ... Arbab-Zadeh, A. (2021). Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome. Journal of cardiovascular computed tomography, 15(6), 485-491. https://doi.org/10.1016/j.jcct.2021.04.005

Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study : Combined CTA/CTP for Long-Term Patient Outcome. / Dewey, Marc; Rochitte, Carlos E.; Ostovaneh, Mohammad R.; Chen, Marcus Y.; George, Richard T.; Niinuma, Hiroyuki; Kitagawa, Kakuya; Laham, Roger; Kofoed, Klaus; Nomura, Cesar; Sakuma, Hajime; Yoshioka, Kunihiro; Mehra, Vishal C.; Jinzaki, Masahiro; Kuribayashi, Sachio; Laule, Michael; Paul, Narinder; Scholte, Arthur J.; Cerci, Rodrigo; Hoe, John; Tan, Swee Yaw; Rybicki, Frank J.; Matheson, Matthew B.; Vavere, Andrea L.; Arai, Andrew E.; Miller, Julie M.; Cox, Christopher ; Brinker, Jeffrey; Clouse, Melvin E.; Di Carli, Marcelo; Lima, João A.C.; Arbab-Zadeh, Armin.

In: Journal of cardiovascular computed tomography, Vol. 15, No. 6, 01.11.2021, p. 485-491.

Research output: Contribution to journal › Article › peer-review

Dewey, M, Rochitte, CE, Ostovaneh, MR, Chen, MY, George, RT, Niinuma, H, Kitagawa, K, Laham, R, Kofoed, K, Nomura, C, Sakuma, H, Yoshioka, K, Mehra, VC, Jinzaki, M, Kuribayashi, S, Laule, M, Paul, N, Scholte, AJ, Cerci, R, Hoe, J, Tan, SY, Rybicki, FJ, Matheson, MB, Vavere, AL, Arai, AE, Miller, JM , Cox, C , Brinker, J, Clouse, ME, Di Carli, M, Lima, JAC & Arbab-Zadeh, A 2021, 'Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome', Journal of cardiovascular computed tomography, vol. 15, no. 6, pp. 485-491. https://doi.org/10.1016/j.jcct.2021.04.005

Dewey M, Rochitte CE, Ostovaneh MR, Chen MY, George RT, Niinuma H et al. Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome. Journal of cardiovascular computed tomography. 2021 Nov 1;15(6):485-491. https://doi.org/10.1016/j.jcct.2021.04.005

Dewey, Marc ; Rochitte, Carlos E. ; Ostovaneh, Mohammad R. ; Chen, Marcus Y. ; George, Richard T. ; Niinuma, Hiroyuki ; Kitagawa, Kakuya ; Laham, Roger ; Kofoed, Klaus ; Nomura, Cesar ; Sakuma, Hajime ; Yoshioka, Kunihiro ; Mehra, Vishal C. ; Jinzaki, Masahiro ; Kuribayashi, Sachio ; Laule, Michael ; Paul, Narinder ; Scholte, Arthur J. ; Cerci, Rodrigo ; Hoe, John ; Tan, Swee Yaw ; Rybicki, Frank J. ; Matheson, Matthew B. ; Vavere, Andrea L. ; Arai, Andrew E. ; Miller, Julie M. ; Cox, Christopher ; Brinker, Jeffrey ; Clouse, Melvin E. ; Di Carli, Marcelo ; Lima, João A.C. ; Arbab-Zadeh, Armin. / Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study : Combined CTA/CTP for Long-Term Patient Outcome. In: Journal of cardiovascular computed tomography. 2021 ; Vol. 15, No. 6. pp. 485-491.

@article{fcf1777037f1497580b9265a4fe19de2,

title = "Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study: Combined CTA/CTP for Long-Term Patient Outcome",

abstract = "Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnormal) was assessed by 5-year major cardiovascular events (MACE) free survival and area under the receiver-operating-characteristic curve (AUC). Results: Follow up beyond 2-years was available in 323 patients. MACE-free survival rate was greater among patients with normal combined CTA-CTP findings compared to ICA-SPECT: 85 vs. 80% (95% confidence interval [CI] for difference 0.1, 11.3) though event-free survival time was similar (4.54 vs. 4.37 years, 95% CI for difference: -0.03, 0.36). Abnormal results by combined CTA-CTP was associated with 3.83 years event-free survival vs. 3.66 years after abnormal combined ICA-SPECT (95% CI for difference: -0.05, 0.39). Predicting MACE by AUC also was similar: 65 vs. 65 (difference 0.1; 95% CI -4.6, 4.9). When MACE was restricted to cardiovascular death, myocardial infarction, or stroke, AUC for CTA-CTP was 71 vs. 60 by ICA-SPECT (difference 11.2; 95% CI -1.0, 19.7). Conclusions: Combined CTA-CTP evaluation yields at least equal 5-year prognostic information as combined ICA-SPECT assessment in patients presenting with suspected coronary artery disease. Noninvasive cardiac CT assessment may eliminate the need for diagnostic cardiac catheterization in many patients. Clinical trial registration: NCT00934037.",

keywords = "CT angiography, Coronary artery disease, Coronary atherosclerosis, Coronary heart disease, Coronary imaging, Myocardial perfusion imaging",

author = "Marc Dewey and Rochitte, {Carlos E.} and Ostovaneh, {Mohammad R.} and Chen, {Marcus Y.} and George, {Richard T.} and Hiroyuki Niinuma and Kakuya Kitagawa and Roger Laham and Klaus Kofoed and Cesar Nomura and Hajime Sakuma and Kunihiro Yoshioka and Mehra, {Vishal C.} and Masahiro Jinzaki and Sachio Kuribayashi and Michael Laule and Narinder Paul and Scholte, {Arthur J.} and Rodrigo Cerci and John Hoe and Tan, {Swee Yaw} and Rybicki, {Frank J.} and Matheson, {Matthew B.} and Vavere, {Andrea L.} and Arai, {Andrew E.} and Miller, {Julie M.} and Christopher Cox and Jeffrey Brinker and Clouse, {Melvin E.} and {Di Carli}, Marcelo and Lima, {Jo{\~a}o A.C.} and Armin Arbab-Zadeh",

note = "Funding Information: This work was funded in part by intramural research support from the NHLBI , National Institutes of Health, USA . The CORE320 cross-sectional study with limited follow up was funded by Canon (formerly Toshiba) Medical Systems. Publisher Copyright: {\textcopyright} 2021 Society of Cardiovascular Computed Tomography",

year = "2021",

month = nov,

day = "1",

doi = "10.1016/j.jcct.2021.04.005",

language = "English (US)",

volume = "15",

pages = "485--491",

journal = "Journal of Cardiovascular Computed Tomography",

issn = "1934-5925",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease — Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study

T2 - Combined CTA/CTP for Long-Term Patient Outcome

AU - Dewey, Marc

AU - Rochitte, Carlos E.

AU - Ostovaneh, Mohammad R.

AU - Chen, Marcus Y.

AU - George, Richard T.

AU - Niinuma, Hiroyuki

AU - Kitagawa, Kakuya

AU - Laham, Roger

AU - Kofoed, Klaus

AU - Nomura, Cesar

AU - Sakuma, Hajime

AU - Yoshioka, Kunihiro

AU - Mehra, Vishal C.

AU - Jinzaki, Masahiro

AU - Kuribayashi, Sachio

AU - Laule, Michael

AU - Paul, Narinder

AU - Scholte, Arthur J.

AU - Cerci, Rodrigo

AU - Hoe, John

AU - Tan, Swee Yaw

AU - Rybicki, Frank J.

AU - Matheson, Matthew B.

AU - Vavere, Andrea L.

AU - Arai, Andrew E.

AU - Miller, Julie M.

AU - Cox, Christopher

AU - Brinker, Jeffrey

AU - Clouse, Melvin E.

AU - Di Carli, Marcelo

AU - Lima, João A.C.

AU - Arbab-Zadeh, Armin

N1 - Funding Information: This work was funded in part by intramural research support from the NHLBI , National Institutes of Health, USA . The CORE320 cross-sectional study with limited follow up was funded by Canon (formerly Toshiba) Medical Systems. Publisher Copyright: © 2021 Society of Cardiovascular Computed Tomography

PY - 2021/11/1

Y1 - 2021/11/1

N2 - Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnormal) was assessed by 5-year major cardiovascular events (MACE) free survival and area under the receiver-operating-characteristic curve (AUC). Results: Follow up beyond 2-years was available in 323 patients. MACE-free survival rate was greater among patients with normal combined CTA-CTP findings compared to ICA-SPECT: 85 vs. 80% (95% confidence interval [CI] for difference 0.1, 11.3) though event-free survival time was similar (4.54 vs. 4.37 years, 95% CI for difference: -0.03, 0.36). Abnormal results by combined CTA-CTP was associated with 3.83 years event-free survival vs. 3.66 years after abnormal combined ICA-SPECT (95% CI for difference: -0.05, 0.39). Predicting MACE by AUC also was similar: 65 vs. 65 (difference 0.1; 95% CI -4.6, 4.9). When MACE was restricted to cardiovascular death, myocardial infarction, or stroke, AUC for CTA-CTP was 71 vs. 60 by ICA-SPECT (difference 11.2; 95% CI -1.0, 19.7). Conclusions: Combined CTA-CTP evaluation yields at least equal 5-year prognostic information as combined ICA-SPECT assessment in patients presenting with suspected coronary artery disease. Noninvasive cardiac CT assessment may eliminate the need for diagnostic cardiac catheterization in many patients. Clinical trial registration: NCT00934037.

AB - Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnormal) was assessed by 5-year major cardiovascular events (MACE) free survival and area under the receiver-operating-characteristic curve (AUC). Results: Follow up beyond 2-years was available in 323 patients. MACE-free survival rate was greater among patients with normal combined CTA-CTP findings compared to ICA-SPECT: 85 vs. 80% (95% confidence interval [CI] for difference 0.1, 11.3) though event-free survival time was similar (4.54 vs. 4.37 years, 95% CI for difference: -0.03, 0.36). Abnormal results by combined CTA-CTP was associated with 3.83 years event-free survival vs. 3.66 years after abnormal combined ICA-SPECT (95% CI for difference: -0.05, 0.39). Predicting MACE by AUC also was similar: 65 vs. 65 (difference 0.1; 95% CI -4.6, 4.9). When MACE was restricted to cardiovascular death, myocardial infarction, or stroke, AUC for CTA-CTP was 71 vs. 60 by ICA-SPECT (difference 11.2; 95% CI -1.0, 19.7). Conclusions: Combined CTA-CTP evaluation yields at least equal 5-year prognostic information as combined ICA-SPECT assessment in patients presenting with suspected coronary artery disease. Noninvasive cardiac CT assessment may eliminate the need for diagnostic cardiac catheterization in many patients. Clinical trial registration: NCT00934037.

KW - CT angiography

KW - Coronary artery disease

KW - Coronary atherosclerosis

KW - Coronary heart disease

KW - Coronary imaging

KW - Myocardial perfusion imaging

UR - http://www.scopus.com/inward/record.url?scp=85106361879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85106361879&partnerID=8YFLogxK

U2 - 10.1016/j.jcct.2021.04.005

DO - 10.1016/j.jcct.2021.04.005

M3 - Article

C2 - 34024757

AN - SCOPUS:85106361879

VL - 15

SP - 485

EP - 491

JO - Journal of Cardiovascular Computed Tomography

JF - Journal of Cardiovascular Computed Tomography

SN - 1934-5925

IS - 6