Prognostic value of myocardial perfusion and ventricular function in a Japanese multicenter cohort study (J-ACCESS): The first-year total events and hard events

Kenichi Nakajima, Hideo Kusuoka, Shigeyuki Nishimura, Akira Yamashina, Tsunehiko Nishimura

Research output: Contribution to journalArticle


Objective: To determine the prognostic value of myocardial ischemia, function and coronary risk factors on total and hard cardiac events using myocardial perfusion imaging in a Japanese population. Methods: A prospective cohort study was performed in 117 Japanese hospitals, each with a nuclear cardiology facility. A total of 4,031 patients with suspected or confirmed ischemic heart disease were registered. The patients were followed up for a year to investigate total and hard events, and those who had any events were followed up for 3 years to evaluate subsequent hard events. A stress-rest gated myocardial perfusion study was performed with 99mTc-tetrofosmin using gated single-photon emission computed tomography (SPECT) and analyzed by semi-quantitative scores. Results: During the 1-year follow-up period, 263 (6.5%) patients had total events comprising all-cause death, non-fatal myocardial infarction (MI), heart failure, unstable angina, angina pectoris and coronary revascularization. Cardiac death occurred in 23 patients (0.6%) and non-fatal MI in 11 (0.3%). Among patients with ejection fraction (EF) of

Original languageEnglish (US)
Pages (from-to)373-381
Number of pages9
JournalAnnals of Nuclear Medicine
Issue number4
Publication statusPublished - Jun 2009
Externally publishedYes



  • Cardiac events
  • Gated SPECT
  • Multi-center study
  • Myocardial perfusion imaging
  • Prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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