TY - JOUR
T1 - Prognostic value of Lauren classification and c-erbB-2 oncogene overexpression in adenocarcinoma of the esophagus and gastroesophageal junction
AU - Polkowski, W.
AU - Van Sandick, J. W.
AU - Offerhaus, G. J A
AU - Ten Kate, F. J W
AU - Mulder, J.
AU - Obertop, H.
AU - Van Lanschot, J. Jan B
PY - 1999/4
Y1 - 1999/4
N2 - Background: The prognostic value of the Lauren classification and of c- erbB-2 oncogene overexpression has been described for gastric cancer. The aim of this study was to investigate the clinical significance of these factors in adenocarcinoma of the esophagus and/or gastroesophageal junction (GEJ). Methods: Forty-one adenocarcinomas of the esophagus and/or GEJ were reviewed for tumor stage, lymph node status, Lauren classification, and c-erbB-2 overexpression, as assessed by immunohistochemical analysis. Results: According to the Lauren classification, tumors were classified as intestinal- , mixed-, or diffuse-type (54%, 32%, and 15%, respectively). Diffuse-type tumors were associated with a significantly worse prognosis than were intestinal-type tumors (P = .018; log-rank test). The prognostic value of the Lauren classification was independent of stage (P = .048; Cox regression model). Overexpression of c-erbB-2 was detected in 24% of the tumors and was present exclusively in intestinal-type tumors and in intestinal-type areas of mixed-type tumors. Ten of the 30 stage III/IV tumors (33%) were c-erbB-2- positive, whereas none of the 11 stage I/II tumors (0%) overexpressed the oncogene product (P = .04; Fisher exact test). The prognostic value of c- erbB-2 overexpression was not independent of stage (P = .7; Cox regression model). Conclusions: (1) The Lauren classification is an independent prognostic factor in adenocarcinoma of the esophagus and GEJ. (2) c-erbB-2 overexpression is limited to (areas of) intestinal-type tumors, indicating that intestinal- and diffuse-type tumors differ oncogenetically. (3) c-erbB- 2 overexpression is associated with the stage of disease, indicating that it is a late event during tumor progression.
AB - Background: The prognostic value of the Lauren classification and of c- erbB-2 oncogene overexpression has been described for gastric cancer. The aim of this study was to investigate the clinical significance of these factors in adenocarcinoma of the esophagus and/or gastroesophageal junction (GEJ). Methods: Forty-one adenocarcinomas of the esophagus and/or GEJ were reviewed for tumor stage, lymph node status, Lauren classification, and c-erbB-2 overexpression, as assessed by immunohistochemical analysis. Results: According to the Lauren classification, tumors were classified as intestinal- , mixed-, or diffuse-type (54%, 32%, and 15%, respectively). Diffuse-type tumors were associated with a significantly worse prognosis than were intestinal-type tumors (P = .018; log-rank test). The prognostic value of the Lauren classification was independent of stage (P = .048; Cox regression model). Overexpression of c-erbB-2 was detected in 24% of the tumors and was present exclusively in intestinal-type tumors and in intestinal-type areas of mixed-type tumors. Ten of the 30 stage III/IV tumors (33%) were c-erbB-2- positive, whereas none of the 11 stage I/II tumors (0%) overexpressed the oncogene product (P = .04; Fisher exact test). The prognostic value of c- erbB-2 overexpression was not independent of stage (P = .7; Cox regression model). Conclusions: (1) The Lauren classification is an independent prognostic factor in adenocarcinoma of the esophagus and GEJ. (2) c-erbB-2 overexpression is limited to (areas of) intestinal-type tumors, indicating that intestinal- and diffuse-type tumors differ oncogenetically. (3) c-erbB- 2 overexpression is associated with the stage of disease, indicating that it is a late event during tumor progression.
KW - C-erbB-2 oncogene
KW - Esophageal adenocarcinoma
KW - Lauren classification
KW - Prognosis
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U2 - 10.1007/s10434-999-0290-2
DO - 10.1007/s10434-999-0290-2
M3 - Article
C2 - 10340889
AN - SCOPUS:0032586731
SN - 1068-9265
VL - 6
SP - 290
EP - 297
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 3
ER -