Prognostic value of diffusion tensor imaging parameters in severe traumatic brain injury

Joshua Francis Betz, Jiachen Zhuo, Anindya Roy, Kathirkamanthan Shanmuganathan, Rao P. Gullapalli

Research output: Contribution to journalArticle

Abstract

Diffusion tensor imaging (DTI) has recently emerged as a useful tool for assessing traumatic brain injury (TBI). In this study, the prognostic value of the relationship between DTI measures and the clinical status of severe TBI patients, both at the time of magnetic resonance imaging (MRI), and their discharge to acute TBI rehabilitation, was assessed. Patients (n=59) admitted to the trauma center with severe closed head injuries were retrospectively evaluated after approval from the institution's institutional review board, to determine the prognostic value of DTI measures. The relationship of DTI measures, including apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial (λ) and radial diffusivity (λ) from the whole brain white matter, internal capsule, genu, splenium, and body of the corpus callosum, were compared with neurological status at MRI and at discharge to acute TBI rehabilitation. Whole brain white matter averages of ADC, λ, and λ, and their coefficient of variation (CV) were significantly correlated with the Glasgow Coma Scale (GCS) score on the day of MRI. The average λ was significantly correlated with GCS scores on the day of MRI in all measured brain regions. Outcomes were associated with whole brain white matter averages of ADC and λ, and the CVs of FA, ADC, λ, and λ; and the averages and CVs of FA and λ in all corpus callosum regions. The inclusion of regional and global DTI measures improved the accuracy of prognostic models, when adjusted for admission GCS score and age (p

Original languageEnglish (US)
Pages (from-to)1292-1305
Number of pages14
JournalJournal of Neurotrauma
Volume29
Issue number7
DOIs
Publication statusPublished - May 1 2012
Externally publishedYes

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Keywords

  • diffusion tensor imaging
  • Glasgow Coma Scale
  • magnetic resonance imaging
  • prognosis
  • severe traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

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