Prognostic value of chronic kidney disease measures in patients with cardiac disease

Research output: Contribution to journalReview article

Abstract

Chronic kidney disease (CKD) is considered a global public health issue. The latest international clinical guideline emphasizes characterization of CKD with both glomerular filtration rate (GFR) and albuminuria. CKD is closely related to cardiac disease and increases the risk of adverse outcomes among patients with cardiovascular disease (CVD). Indeed, numerous studies have investigated the association of CKD measures with prognosis among patients with CVD, but most of them have focused on kidney function, with limited data on albuminuria. Consequently, although there are several risk prediction tools for patients with CVD incorporating kidney function, to our knowledge, none of them include albuminuria. Moreover, the selection of the kidney function measure (e.g., serum creatinine, creatinine-based estimated GFR, or blood urea nitrogen) in these tools is heterogeneous. In this review, we will summarize these aspects, as well as the burden of CKD in patients with CVD, in the current literature. We will also discuss potential mechanisms linking CKD to secondary events and consider future research directions. Given their clinical and public health importance, for CVD we will focus on 2 representative cardiac diseases: myocardial infarction and heart failure.

Original languageEnglish (US)
Pages (from-to)1075-1084
Number of pages10
JournalCirculation Journal
Volume81
Issue number8
DOIs
StatePublished - 2017

Fingerprint

Chronic Renal Insufficiency
Heart Diseases
Cardiovascular Diseases
Albuminuria
Glomerular Filtration Rate
Kidney
Creatinine
Heart Failure
Public Health
Blood Urea Nitrogen
Myocardial Infarction
Guidelines
Serum

Keywords

  • Albuminuria
  • Chronic kidney disease
  • Heart failure
  • Myocardial infarction
  • Risk prediction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prognostic value of chronic kidney disease measures in patients with cardiac disease. / Mok, Yejin; Ballew, Shoshana; Matsushita, Kunihiro.

In: Circulation Journal, Vol. 81, No. 8, 2017, p. 1075-1084.

Research output: Contribution to journalReview article

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N2 - Chronic kidney disease (CKD) is considered a global public health issue. The latest international clinical guideline emphasizes characterization of CKD with both glomerular filtration rate (GFR) and albuminuria. CKD is closely related to cardiac disease and increases the risk of adverse outcomes among patients with cardiovascular disease (CVD). Indeed, numerous studies have investigated the association of CKD measures with prognosis among patients with CVD, but most of them have focused on kidney function, with limited data on albuminuria. Consequently, although there are several risk prediction tools for patients with CVD incorporating kidney function, to our knowledge, none of them include albuminuria. Moreover, the selection of the kidney function measure (e.g., serum creatinine, creatinine-based estimated GFR, or blood urea nitrogen) in these tools is heterogeneous. In this review, we will summarize these aspects, as well as the burden of CKD in patients with CVD, in the current literature. We will also discuss potential mechanisms linking CKD to secondary events and consider future research directions. Given their clinical and public health importance, for CVD we will focus on 2 representative cardiac diseases: myocardial infarction and heart failure.

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