Prognostic value of cell proliferation (Ki-67 antigen) and nuclear DNA content in clinically resectable, distal bile duct carcinoma

Arjen M. Rijken, Akiko Umezawa, Thomas M. Van Gulik, Anne Bosma, Mirjam M. Polak, G. Johan A Offerhaus, Huug Obertop, Dirk J. Gouma

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to investigate the prognostic value of celt proliferation (Ki-67 antigen) and DNA content in patients resected for distal bile duct carcinoma (DBDC). Methods: Formalin-fixed tumor specimens of 35 patients with resected DBDC and a long-term clinical follow- up were analyzed. MIB-1 antibody was used for Ki-67 antigen detection to determine the proportion of proliferating cells. DNA content was measured using flow cytometry. Results: A significant correlation was found between a low MIB-1 index (

Original languageEnglish (US)
Pages (from-to)699-705
Number of pages7
JournalAnnals of Surgical Oncology
Volume5
Issue number8
StatePublished - Dec 1998
Externally publishedYes

Keywords

  • Bile duct carcinoma
  • Cell proliferation
  • Ki-67 antigen
  • Nuclear DNA content
  • Prognostication

ASJC Scopus subject areas

  • Surgery
  • Oncology

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