Prognostic use of mean ovarian volume in in vitro fertilization cycles: A prospective assessment

John L. Frattarelli, Andrew J. Levi, Bradley T. Miller, James Segars

Research output: Contribution to journalArticle

Abstract

To determine the predictive value and to define prognostic threshold measurements for mean ovarian volume (MOV) in patients undergoing IVF. Prospective cohort analysis. Tertiary care center. Two hundred sixty-seven patients. Transvaginal ultrasound before starting gonadotropins. Number of oocytes retrieved, basal hormone levels, and cycle outcomes. The MOV for the population was 4.78 ± 2.6 cm 3 (range 0.9-21.1 cm 3). The MOV significantly correlated with the majority of prestimulation and poststimulation IVF parameters. Threshold analysis demonstrated a lower pregnancy rate associated with a MOV of 3 (31.6% vs. 55.6%). Threshold analysis revealed a trend toward higher cancellation rate associated with a MOV of 3 (21.1% vs. 7.3%). Although MOV correlated with IVF stimulation parameters, its use as an adjunct in counseling patients during IVF appears to be of limited value. A MOV 3 was associated clinically with a higher cancellation rate (21.1%) and a lower pregnancy rate (31.6%) in those cycles not cancelled. However, these values do not deviate far from the mean national IVF outcome rates. There was no absolute MOV that was predictive of pregnancy outcome or cycle cancellation.

Original languageEnglish (US)
Pages (from-to)811-815
Number of pages5
JournalFertility and Sterility
Volume82
Issue number4
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Fertilization in Vitro
Pregnancy Rate
Pregnancy Outcome
Gonadotropins
Tertiary Care Centers
Oocytes
Counseling
Cohort Studies
Hormones
Population

Keywords

  • basal antral follicle count
  • cancellation rate
  • clinical outcome
  • In vitro fertilization
  • mean ovarian volume
  • ovarian reserve
  • ovarian response
  • predictive value
  • pregnancy
  • review

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Prognostic use of mean ovarian volume in in vitro fertilization cycles : A prospective assessment. / Frattarelli, John L.; Levi, Andrew J.; Miller, Bradley T.; Segars, James.

In: Fertility and Sterility, Vol. 82, No. 4, 10.2004, p. 811-815.

Research output: Contribution to journalArticle

Frattarelli, John L. ; Levi, Andrew J. ; Miller, Bradley T. ; Segars, James. / Prognostic use of mean ovarian volume in in vitro fertilization cycles : A prospective assessment. In: Fertility and Sterility. 2004 ; Vol. 82, No. 4. pp. 811-815.
@article{5e93b3974ad4485096532b12f52e4bf4,
title = "Prognostic use of mean ovarian volume in in vitro fertilization cycles: A prospective assessment",
abstract = "To determine the predictive value and to define prognostic threshold measurements for mean ovarian volume (MOV) in patients undergoing IVF. Prospective cohort analysis. Tertiary care center. Two hundred sixty-seven patients. Transvaginal ultrasound before starting gonadotropins. Number of oocytes retrieved, basal hormone levels, and cycle outcomes. The MOV for the population was 4.78 ± 2.6 cm 3 (range 0.9-21.1 cm 3). The MOV significantly correlated with the majority of prestimulation and poststimulation IVF parameters. Threshold analysis demonstrated a lower pregnancy rate associated with a MOV of 3 (31.6{\%} vs. 55.6{\%}). Threshold analysis revealed a trend toward higher cancellation rate associated with a MOV of 3 (21.1{\%} vs. 7.3{\%}). Although MOV correlated with IVF stimulation parameters, its use as an adjunct in counseling patients during IVF appears to be of limited value. A MOV 3 was associated clinically with a higher cancellation rate (21.1{\%}) and a lower pregnancy rate (31.6{\%}) in those cycles not cancelled. However, these values do not deviate far from the mean national IVF outcome rates. There was no absolute MOV that was predictive of pregnancy outcome or cycle cancellation.",
keywords = "basal antral follicle count, cancellation rate, clinical outcome, In vitro fertilization, mean ovarian volume, ovarian reserve, ovarian response, predictive value, pregnancy, review",
author = "Frattarelli, {John L.} and Levi, {Andrew J.} and Miller, {Bradley T.} and James Segars",
year = "2004",
month = "10",
doi = "10.1016/j.fertnstert.2004.02.143",
language = "English (US)",
volume = "82",
pages = "811--815",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Prognostic use of mean ovarian volume in in vitro fertilization cycles

T2 - A prospective assessment

AU - Frattarelli, John L.

AU - Levi, Andrew J.

AU - Miller, Bradley T.

AU - Segars, James

PY - 2004/10

Y1 - 2004/10

N2 - To determine the predictive value and to define prognostic threshold measurements for mean ovarian volume (MOV) in patients undergoing IVF. Prospective cohort analysis. Tertiary care center. Two hundred sixty-seven patients. Transvaginal ultrasound before starting gonadotropins. Number of oocytes retrieved, basal hormone levels, and cycle outcomes. The MOV for the population was 4.78 ± 2.6 cm 3 (range 0.9-21.1 cm 3). The MOV significantly correlated with the majority of prestimulation and poststimulation IVF parameters. Threshold analysis demonstrated a lower pregnancy rate associated with a MOV of 3 (31.6% vs. 55.6%). Threshold analysis revealed a trend toward higher cancellation rate associated with a MOV of 3 (21.1% vs. 7.3%). Although MOV correlated with IVF stimulation parameters, its use as an adjunct in counseling patients during IVF appears to be of limited value. A MOV 3 was associated clinically with a higher cancellation rate (21.1%) and a lower pregnancy rate (31.6%) in those cycles not cancelled. However, these values do not deviate far from the mean national IVF outcome rates. There was no absolute MOV that was predictive of pregnancy outcome or cycle cancellation.

AB - To determine the predictive value and to define prognostic threshold measurements for mean ovarian volume (MOV) in patients undergoing IVF. Prospective cohort analysis. Tertiary care center. Two hundred sixty-seven patients. Transvaginal ultrasound before starting gonadotropins. Number of oocytes retrieved, basal hormone levels, and cycle outcomes. The MOV for the population was 4.78 ± 2.6 cm 3 (range 0.9-21.1 cm 3). The MOV significantly correlated with the majority of prestimulation and poststimulation IVF parameters. Threshold analysis demonstrated a lower pregnancy rate associated with a MOV of 3 (31.6% vs. 55.6%). Threshold analysis revealed a trend toward higher cancellation rate associated with a MOV of 3 (21.1% vs. 7.3%). Although MOV correlated with IVF stimulation parameters, its use as an adjunct in counseling patients during IVF appears to be of limited value. A MOV 3 was associated clinically with a higher cancellation rate (21.1%) and a lower pregnancy rate (31.6%) in those cycles not cancelled. However, these values do not deviate far from the mean national IVF outcome rates. There was no absolute MOV that was predictive of pregnancy outcome or cycle cancellation.

KW - basal antral follicle count

KW - cancellation rate

KW - clinical outcome

KW - In vitro fertilization

KW - mean ovarian volume

KW - ovarian reserve

KW - ovarian response

KW - predictive value

KW - pregnancy

KW - review

UR - http://www.scopus.com/inward/record.url?scp=5144224305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5144224305&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2004.02.143

DO - 10.1016/j.fertnstert.2004.02.143

M3 - Article

C2 - 15482752

AN - SCOPUS:5144224305

VL - 82

SP - 811

EP - 815

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 4

ER -