Prognostic study of cardiac and renal events in japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT: J-ACCESS 3 study design

Satoko Nakamura, Yuhei Kawano, Hiroki Hase, Tsuguru Hatta, Shigeyuki Nishimura, Masao Moroi, Susumu Nakagawa, Tokuo Kasai, Hideo Kusuoka, Yasuchika Takeishi, Kenichi Nakajima, Mitsuru Momose, Kazuya Takehana, Mamoru Nanasato, Syunichi Yoda, Hidetaka Nishina, Naoya Matsumoto, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease. Recent studies have indicated that the incidence of cardiovascular disease increases inversely with estimated glomerular filtration rate. Although coronary angiography is considered the gold standard for detecting coronary artery disease, contrast-induced nephropathy or cholesterol microembolization remain serious problems; therefore, a method of detecting coronary artery disease without renal deterioration is desirable. From this viewpoint, stress myocardial perfusion single photon emission computed tomography (SPECT) might be useful for patients with chronic kidney disease. We recently performed the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS) investigating patients with suspected or extant coronary artery disease and the J-ACCESS 2 study of patients with diabetes. The findings from these studies showed that SPECT can detect coronary artery disease and help to predict future cardiac events. Thus, we proposed a multicenter, prospective cohort study called "J-ACCESS 3" in patients with chronic kidney disease and cardiovascular risk. The study aimed at predicting cardiovascular and renal events based on myocardial perfusion imaging and clinical backgrounds. We began enrolling patients in J-ACCESS 3 at 74 facilities from April 2009 and will continue to do so until 31 March 2010, with the aim of having a cohort of 800 patients. These will be followed up for three years. The primary endpoints will be cardiac death and sudden death. The secondary endpoints will comprise any cardiovascular or renal events. This study will be completed in 2013. Here, we describe the design of the J-ACCESS 3 study.

Original languageEnglish (US)
Pages (from-to)379-385
Number of pages7
JournalTherapeutic Apheresis and Dialysis
Volume14
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

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Single-Photon Emission-Computed Tomography
Chronic Renal Insufficiency
Perfusion
Kidney
Coronary Artery Disease
Cardiovascular Diseases
Myocardial Perfusion Imaging
Sudden Death
Coronary Angiography
Glomerular Filtration Rate
Cohort Studies
Cholesterol
Prospective Studies
Morbidity
Survival
Mortality
Incidence

Keywords

  • Chronic kidney disease
  • Glomerular filtration rate
  • Myocardial perfusion imaging
  • Public health
  • Single photon emission computed tomography

ASJC Scopus subject areas

  • Hematology
  • Nephrology
  • Medicine(all)

Cite this

Prognostic study of cardiac and renal events in japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT : J-ACCESS 3 study design. / Nakamura, Satoko; Kawano, Yuhei; Hase, Hiroki; Hatta, Tsuguru; Nishimura, Shigeyuki; Moroi, Masao; Nakagawa, Susumu; Kasai, Tokuo; Kusuoka, Hideo; Takeishi, Yasuchika; Nakajima, Kenichi; Momose, Mitsuru; Takehana, Kazuya; Nanasato, Mamoru; Yoda, Syunichi; Nishina, Hidetaka; Matsumoto, Naoya; Nishimura, Tsunehiko.

In: Therapeutic Apheresis and Dialysis, Vol. 14, No. 4, 2010, p. 379-385.

Research output: Contribution to journalArticle

Nakamura, S, Kawano, Y, Hase, H, Hatta, T, Nishimura, S, Moroi, M, Nakagawa, S, Kasai, T, Kusuoka, H, Takeishi, Y, Nakajima, K, Momose, M, Takehana, K, Nanasato, M, Yoda, S, Nishina, H, Matsumoto, N & Nishimura, T 2010, 'Prognostic study of cardiac and renal events in japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT: J-ACCESS 3 study design', Therapeutic Apheresis and Dialysis, vol. 14, no. 4, pp. 379-385. https://doi.org/10.1111/j.1744-9987.2010.00823.x
Nakamura, Satoko ; Kawano, Yuhei ; Hase, Hiroki ; Hatta, Tsuguru ; Nishimura, Shigeyuki ; Moroi, Masao ; Nakagawa, Susumu ; Kasai, Tokuo ; Kusuoka, Hideo ; Takeishi, Yasuchika ; Nakajima, Kenichi ; Momose, Mitsuru ; Takehana, Kazuya ; Nanasato, Mamoru ; Yoda, Syunichi ; Nishina, Hidetaka ; Matsumoto, Naoya ; Nishimura, Tsunehiko. / Prognostic study of cardiac and renal events in japanese patients with chronic kidney disease and cardiovascular risk using myocardial perfusion SPECT : J-ACCESS 3 study design. In: Therapeutic Apheresis and Dialysis. 2010 ; Vol. 14, No. 4. pp. 379-385.
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AU - Nakamura, Satoko

AU - Kawano, Yuhei

AU - Hase, Hiroki

AU - Hatta, Tsuguru

AU - Nishimura, Shigeyuki

AU - Moroi, Masao

AU - Nakagawa, Susumu

AU - Kasai, Tokuo

AU - Kusuoka, Hideo

AU - Takeishi, Yasuchika

AU - Nakajima, Kenichi

AU - Momose, Mitsuru

AU - Takehana, Kazuya

AU - Nanasato, Mamoru

AU - Yoda, Syunichi

AU - Nishina, Hidetaka

AU - Matsumoto, Naoya

AU - Nishimura, Tsunehiko

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N2 - Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease. Recent studies have indicated that the incidence of cardiovascular disease increases inversely with estimated glomerular filtration rate. Although coronary angiography is considered the gold standard for detecting coronary artery disease, contrast-induced nephropathy or cholesterol microembolization remain serious problems; therefore, a method of detecting coronary artery disease without renal deterioration is desirable. From this viewpoint, stress myocardial perfusion single photon emission computed tomography (SPECT) might be useful for patients with chronic kidney disease. We recently performed the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS) investigating patients with suspected or extant coronary artery disease and the J-ACCESS 2 study of patients with diabetes. The findings from these studies showed that SPECT can detect coronary artery disease and help to predict future cardiac events. Thus, we proposed a multicenter, prospective cohort study called "J-ACCESS 3" in patients with chronic kidney disease and cardiovascular risk. The study aimed at predicting cardiovascular and renal events based on myocardial perfusion imaging and clinical backgrounds. We began enrolling patients in J-ACCESS 3 at 74 facilities from April 2009 and will continue to do so until 31 March 2010, with the aim of having a cohort of 800 patients. These will be followed up for three years. The primary endpoints will be cardiac death and sudden death. The secondary endpoints will comprise any cardiovascular or renal events. This study will be completed in 2013. Here, we describe the design of the J-ACCESS 3 study.

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KW - Public health

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