Prognostic significance (relapse, non-relapse) of nuclear shape parameters in lymph node negative breast cancer

Christopher Umbricht, Martin Oberholzer, Ruedi Gschwind, Heinz Christen, Joachim Torhorst

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A series of 15 postmenopausal patients with stage I invasive breast cancer (pT1-2, pNO, cMO) of uniform histologic type (ductal, NOS) was selected from the Basel Cancer Registry for retrospective analysis. A group of seven patients with a minimal disease-free survival of 9 years was compared to a group of eight patients with clinical and/or histopathological relapse within 8 years of mastectomy. Computer-assisted morphometry of cancer nuclei in routine histological material was used to investigate possible correlations of clinical outcome with nuclear size and shape parameters. Significant differences were found for certain shape descriptors by nonparametric statistical analysis. Stepwise discriminant analysis was applied to find the best combination of parameters separating the two prognostic groups. Application of the 'leaving one out method' showed correct classification in 6 of 8 recurrent cases and in all non-recurrent cases. The number of patients is small, therefore the results should be carefully interpreted.

Original languageEnglish (US)
Pages (from-to)11-23
Number of pages13
JournalAnalytical Cellular Pathology
Issue number1
StatePublished - Feb 1989
Externally publishedYes


  • Breast cancer (lymph node negative)
  • Morphometry
  • Prognosis
  • Shape of nuclei

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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