Prognostic significance of the labeling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms

Martin Tobi, James Hatfield, Volkan Adsay, Katherine Galagan, Richard Kozarek, Mitsuhiro Inagaki, Shinichi Kasai, Yoshihiko Tokusashi, Takeshi Obara, Ralph H. Hruban, John Lough, Alan N. Barkun, Mansour Jabbari, Rafiq Sheikh, Boris Ruebner, Michael J. Lawson, Edgar Ben-Josef, Suzanne Fligiel

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Pancreatic intraductal papillary mucinous neoplasms (IPMN), morphologically resembling colonic adenomas, often have an indefinable malignant potential. We used a monoclonal antibody (MAb) raised against colonic adenomas, Adnab-9, to identify patients with a better prognosis. Methods. We assessed Adnab-9-labeled sections of these neoplasms from 50 patients, 13 pancreatic adenocarcinomas, and 32 colonic adenomas using standard immunohistochemical techniques. Results. 26% of the IPMNs labeled with Adnab-9 as compared to 0% of pancreatic ductal cancers or surrounding benign tissues, (p < 0.001) and 53% of adenomas (p < 0.025). Labeling in IPMNs was usually seen in the noninvasive epithelium suggesting that Adnab-9 is a premalignant marker in these lesions. Labeling of invasive IPMN's identified a group of patients with a superior overall survival (p = 0.027). Conclusion. Adnab-9 labeling-characteristics appear similar for both IPMNs and adenomatous polyps, suggesting that they are analogous lesions. Adnab-9 labeling may also be a useful prognostic marker for invasive intraductal papillary mucinous neoplasms.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalInternational Journal of Pancreatology
Volume29
Issue number3
DOIs
StatePublished - Jan 1 2001

Keywords

  • Colorectal cancer
  • Immunostaining
  • Intraductal papillary mucinous neoplasms
  • Monoclonal antibody
  • Pancreatic ductal cancer
  • Severely dysplastic adenomatous colonic polyps

ASJC Scopus subject areas

  • Oncology
  • Endocrinology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Prognostic significance of the labeling of Adnab-9 in pancreatic intraductal papillary mucinous neoplasms'. Together they form a unique fingerprint.

Cite this