Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: A systematic review and meta-analysis

Marc L. Ooft; Weibel W. Braunius; Paulien Heus; Inge Stegeman; Paul J. Van Diest; Wilko Grolman; Charlotte I. Zuur; Stefan M. Willems

doi:10.2217/bmm.15.68

Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: A systematic review and meta-analysis

Marc L. Ooft, Weibel W. Braunius, Paulien Heus, Inge Stegeman, Paul J. Van Diest, Wilko Grolman, Charlotte I. Zuur, Stefan M. Willems

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: To evaluate the prognostic impact of the EGF receptor (EGFR) pathway molecules and assess their clinical usefulness. Methods: We conducted a systematic review. Pubmed and EMBASE were searched January 2014. The prognostic relevance of EGFR, JAK, PI3K, PIK3CA, STAT3, STAT5, PTEN, AKT, mTOR, GRB2, SOS, RAF, RAS, MAPK, ERK, MEK and CCND1 in nasopharyngeal carcinoma was assessed. The outcomes considered were overall survival, disease-free survival and tumor-node-metastasis stage. Twenty-two studies were included. Risk of bias was evaluated. Meta-analysis for which pooled hazard ratios and 95% CIs were calculated. Conclusion: EGFR overexpression predicts a worse overall survival and disease-free survival in nasopharyngeal carcinoma, but no specific causal pathway molecule could be identified.

Original language	English (US)
Pages (from-to)	997-1010
Number of pages	14
Journal	Biomarkers in Medicine
Volume	9
Issue number	10
DOIs	https://doi.org/10.2217/bmm.15.68
State	Published - Oct 1 2015
Externally published	Yes

Keywords

cancer
EGFR
epidermal growth factor receptor pathway
meta-analysis
nasopharyngeal cancer
nasopharyngeal carcinoma
outcome
prognosis
review
survival

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical
Drug Discovery

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title = "Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: A systematic review and meta-analysis",

abstract = "Objective: To evaluate the prognostic impact of the EGF receptor (EGFR) pathway molecules and assess their clinical usefulness. Methods: We conducted a systematic review. Pubmed and EMBASE were searched January 2014. The prognostic relevance of EGFR, JAK, PI3K, PIK3CA, STAT3, STAT5, PTEN, AKT, mTOR, GRB2, SOS, RAF, RAS, MAPK, ERK, MEK and CCND1 in nasopharyngeal carcinoma was assessed. The outcomes considered were overall survival, disease-free survival and tumor-node-metastasis stage. Twenty-two studies were included. Risk of bias was evaluated. Meta-analysis for which pooled hazard ratios and 95% CIs were calculated. Conclusion: EGFR overexpression predicts a worse overall survival and disease-free survival in nasopharyngeal carcinoma, but no specific causal pathway molecule could be identified.",

keywords = "cancer, EGFR, epidermal growth factor receptor pathway, meta-analysis, nasopharyngeal cancer, nasopharyngeal carcinoma, outcome, prognosis, review, survival",

author = "Ooft, {Marc L.} and Braunius, {Weibel W.} and Paulien Heus and Inge Stegeman and {Van Diest}, {Paul J.} and Wilko Grolman and Zuur, {Charlotte I.} and Willems, {Stefan M.}",

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doi = "10.2217/bmm.15.68",

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T2 - A systematic review and meta-analysis

AU - Ooft, Marc L.

AU - Braunius, Weibel W.

AU - Heus, Paulien

AU - Stegeman, Inge

AU - Van Diest, Paul J.

AU - Grolman, Wilko

AU - Zuur, Charlotte I.

AU - Willems, Stefan M.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objective: To evaluate the prognostic impact of the EGF receptor (EGFR) pathway molecules and assess their clinical usefulness. Methods: We conducted a systematic review. Pubmed and EMBASE were searched January 2014. The prognostic relevance of EGFR, JAK, PI3K, PIK3CA, STAT3, STAT5, PTEN, AKT, mTOR, GRB2, SOS, RAF, RAS, MAPK, ERK, MEK and CCND1 in nasopharyngeal carcinoma was assessed. The outcomes considered were overall survival, disease-free survival and tumor-node-metastasis stage. Twenty-two studies were included. Risk of bias was evaluated. Meta-analysis for which pooled hazard ratios and 95% CIs were calculated. Conclusion: EGFR overexpression predicts a worse overall survival and disease-free survival in nasopharyngeal carcinoma, but no specific causal pathway molecule could be identified.

AB - Objective: To evaluate the prognostic impact of the EGF receptor (EGFR) pathway molecules and assess their clinical usefulness. Methods: We conducted a systematic review. Pubmed and EMBASE were searched January 2014. The prognostic relevance of EGFR, JAK, PI3K, PIK3CA, STAT3, STAT5, PTEN, AKT, mTOR, GRB2, SOS, RAF, RAS, MAPK, ERK, MEK and CCND1 in nasopharyngeal carcinoma was assessed. The outcomes considered were overall survival, disease-free survival and tumor-node-metastasis stage. Twenty-two studies were included. Risk of bias was evaluated. Meta-analysis for which pooled hazard ratios and 95% CIs were calculated. Conclusion: EGFR overexpression predicts a worse overall survival and disease-free survival in nasopharyngeal carcinoma, but no specific causal pathway molecule could be identified.

KW - cancer

KW - EGFR

KW - epidermal growth factor receptor pathway

KW - meta-analysis

KW - nasopharyngeal cancer

KW - nasopharyngeal carcinoma

KW - outcome

KW - prognosis

KW - review

KW - survival

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Prognostic significance of the EGFR pathway in nasopharyngeal carcinoma: A systematic review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

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