Abstract
BACKGROUND. The prognostic significance of the presence of a neuroendocrine marker (synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. METHODS. A multicentric retrospective study was conducted with immunohistochemical staining in a single center of 318 patients resected for squamous carcinoma or adenocarcinoma in pathologic stage I. RESULTS. In all, 162 cases of squamous carcinoma and 156 cases of adenocarcinoma were identified, which included 105 patients in stage IA (50 patients with squamous carcinoma and 55 patients with adenocarcinoma) and 213 in stage IB (112 with squamous carcinoma and 101 with adenocarcinoma). Eighty-six tumors showed a presence of SY+ (27%). Univariate analysis showed lower survival rates at 5 years for those patients older than 70 years of age compared with those patients younger than 70 years of age (60.35% vs 70.57%; P = .007) and for those patients with SY+ compared with those with SY- (52.48% vs 72.68%; P = .0017). Patients with SY+ tumors showed a higher rate of recurrence than patients with SY- tumors (50% vs 33.6%; P = .008). Multivariate analysis showed that those patients greater that 70 years of age (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.14-2.65) and the presence of SY (HR, 2.15; 95% CI, 1.40-3.30) were significant independent prognostic factors associated with a poor outcome. CONCLUSIONS. Stage I of squamous carcinoma and adenocarcinoma of the lung with SY+ has a poor prognosis, with a higher frequency of recurrence and lower survival rates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1776-1781 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 110 |
| Issue number | 8 |
| DOIs | |
| State | Published - Oct 15 2007 |
| Externally published | Yes |
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Keywords
- Immunohistochemistry
- Neuroendocrine differentiation
- Squamous carcinoma and adenocarcinoma of the lung
- Survival
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung. / González-Aragoneses, Federico; Moreno-Mata, Nicolás; Cebollero-Presmanes, María; García-Yuste, Mariano; Cañizares-Carretero, Miguel Ángel; Molins-López-Rodó, Laureano; Quevedo-Losada, Santiago; Torres-Lanzas, Juan; Álvarez-Fernández, Emilio; Almaraz, Ana; Muñoz, María F.; Travis, William D.; Battafarano, Richard J; Fuentes, Pierre.
In: Cancer, Vol. 110, No. 8, 15.10.2007, p. 1776-1781.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic significance of synaptophysin in stage I of squamous carcinoma and adenocarcinoma of the lung
AU - González-Aragoneses, Federico
AU - Moreno-Mata, Nicolás
AU - Cebollero-Presmanes, María
AU - García-Yuste, Mariano
AU - Cañizares-Carretero, Miguel Ángel
AU - Molins-López-Rodó, Laureano
AU - Quevedo-Losada, Santiago
AU - Torres-Lanzas, Juan
AU - Álvarez-Fernández, Emilio
AU - Almaraz, Ana
AU - Muñoz, María F.
AU - Travis, William D.
AU - Battafarano, Richard J
AU - Fuentes, Pierre
PY - 2007/10/15
Y1 - 2007/10/15
N2 - BACKGROUND. The prognostic significance of the presence of a neuroendocrine marker (synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. METHODS. A multicentric retrospective study was conducted with immunohistochemical staining in a single center of 318 patients resected for squamous carcinoma or adenocarcinoma in pathologic stage I. RESULTS. In all, 162 cases of squamous carcinoma and 156 cases of adenocarcinoma were identified, which included 105 patients in stage IA (50 patients with squamous carcinoma and 55 patients with adenocarcinoma) and 213 in stage IB (112 with squamous carcinoma and 101 with adenocarcinoma). Eighty-six tumors showed a presence of SY+ (27%). Univariate analysis showed lower survival rates at 5 years for those patients older than 70 years of age compared with those patients younger than 70 years of age (60.35% vs 70.57%; P = .007) and for those patients with SY+ compared with those with SY- (52.48% vs 72.68%; P = .0017). Patients with SY+ tumors showed a higher rate of recurrence than patients with SY- tumors (50% vs 33.6%; P = .008). Multivariate analysis showed that those patients greater that 70 years of age (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.14-2.65) and the presence of SY (HR, 2.15; 95% CI, 1.40-3.30) were significant independent prognostic factors associated with a poor outcome. CONCLUSIONS. Stage I of squamous carcinoma and adenocarcinoma of the lung with SY+ has a poor prognosis, with a higher frequency of recurrence and lower survival rates.
AB - BACKGROUND. The prognostic significance of the presence of a neuroendocrine marker (synaptophysin, SY) was analyzed in stage I of squamous carcinoma and adenocarcinoma of the lung. METHODS. A multicentric retrospective study was conducted with immunohistochemical staining in a single center of 318 patients resected for squamous carcinoma or adenocarcinoma in pathologic stage I. RESULTS. In all, 162 cases of squamous carcinoma and 156 cases of adenocarcinoma were identified, which included 105 patients in stage IA (50 patients with squamous carcinoma and 55 patients with adenocarcinoma) and 213 in stage IB (112 with squamous carcinoma and 101 with adenocarcinoma). Eighty-six tumors showed a presence of SY+ (27%). Univariate analysis showed lower survival rates at 5 years for those patients older than 70 years of age compared with those patients younger than 70 years of age (60.35% vs 70.57%; P = .007) and for those patients with SY+ compared with those with SY- (52.48% vs 72.68%; P = .0017). Patients with SY+ tumors showed a higher rate of recurrence than patients with SY- tumors (50% vs 33.6%; P = .008). Multivariate analysis showed that those patients greater that 70 years of age (hazard ratio [HR], 1.74; 95% confidence interval [CI], 1.14-2.65) and the presence of SY (HR, 2.15; 95% CI, 1.40-3.30) were significant independent prognostic factors associated with a poor outcome. CONCLUSIONS. Stage I of squamous carcinoma and adenocarcinoma of the lung with SY+ has a poor prognosis, with a higher frequency of recurrence and lower survival rates.
KW - Immunohistochemistry
KW - Neuroendocrine differentiation
KW - Squamous carcinoma and adenocarcinoma of the lung
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=35048862036&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35048862036&partnerID=8YFLogxK
U2 - 10.1002/cncr.22985
DO - 10.1002/cncr.22985
M3 - Article
C2 - 17724707
AN - SCOPUS:35048862036
VL - 110
SP - 1776
EP - 1781
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 8
ER -