Prognostic Significance of Presentation-to-Diagnosis Interval in Patients with Oropharyngeal Carcinoma

Tang Ho, Marianna Zahurak, Wayne Martin Koch

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the prognostic impact of presentation-to-diagnosis interval (PDI) and its association with other clinical factors in patients with oropharyngeal squamous cell carcinoma (OpSCC). Design: Retrospective cohort study. Setting: Otolaryngology clinic of an academic medical center. Patients: Eighty-seven patients with OpSCC referred to the otolaryngology service at theJohns Hopkins Medical Institutions from March 1994 to August 2001 were included in the study. Selection criteria included confirmed pathological diagnosis of OpSCC, availability of referral record for PDI determination, and no past history of oropharyngeal cancer. Main Outcome Measures: The PDI is defined as the time between the patient's first presentation to a medical professional for tumor-related symptoms and the time when the diagnosis of OpSCC was made. The prognostic impact of PDI and its association with other clinical factors were assessed using univariate and multivariate analyses. Results: Forty percent of patients (35/87) had a PDI of 3 months or longer. Referred otalgia, active smoking status at the time of diagnosis, stage IV disease, and advanced T stage were associated with a poor prognosis. Prolonged PDI itself was not associated with a significant decrease in survival in univariate analysis (hazard ratio, 1.27; P=.52). Furthermore, no significant correlation was found between PDI and N stage, T stage, young age at presentation (

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalArchives of Otolaryngology--Head and Neck Surgery
Volume130
Issue number1
DOIs
StatePublished - Jan 2004

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Carcinoma
Squamous Cell Carcinoma
Otolaryngology
Earache
Oropharyngeal Neoplasms
Patient Selection
Cohort Studies
Referral and Consultation
Multivariate Analysis
Retrospective Studies
Smoking
Outcome Assessment (Health Care)
Survival
Neoplasms

ASJC Scopus subject areas

  • Otorhinolaryngology

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Prognostic Significance of Presentation-to-Diagnosis Interval in Patients with Oropharyngeal Carcinoma. / Ho, Tang; Zahurak, Marianna; Koch, Wayne Martin.

In: Archives of Otolaryngology--Head and Neck Surgery, Vol. 130, No. 1, 01.2004, p. 45-51.

Research output: Contribution to journalArticle

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