TY - JOUR
T1 - Prognostic significance of p53 immunoreactivity in adult patients with supratentorial fibrillary astrocytic neoplasms
AU - Montine, Thomas J.
AU - Bruner, Janet M.
AU - Vandersteenhoven, Jacob J.
AU - Dodge, Richard K.
AU - Burger, Peter C.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1994/12
Y1 - 1994/12
N2 - The prognostic significance of p53 immunoreactivity in adult patients with supratentorial fibrillary astrocytic neoplasms was examined by Kaplan-Meier survival analysis. Using a monoclonal antibody that reacts with both mutant and wild-type p53 protein (PAb 1801), reactivity was assessed immunohistochemically in specimens from the first diagnosis of astrocytic neoplasm in 95 patients: 26 astrocytomas (A), 19 anaplastic astrocytomas (AA). and 50 glioblastomas multiforme (GBM). Overall, 539c of cases exhibited any p53 nuclear immunoreactivity, with approximately the same proportion in each histologic grade. Survival was measured from diagnosis to death or last follow-up and ranged from 3 months to 9 years. Histologic grade was a powerful prognostic variable for this group of patients (p < 0.001), with median survivals of 88, 18, and 9 months for A, AA, and GBM patients, respectively. In contrast, patients with p53-immunoreactive or -nonimmunoreactive neoplasms had median survival times of 18 or 15 months, respectively (p = 0.21). These results indicate that p53 immunoreactivity was not prog-nostically significant in this group of adult patients with supratentorial fibrillary astrocytic neoplasms, although a small difference in survival cannot be excluded.
AB - The prognostic significance of p53 immunoreactivity in adult patients with supratentorial fibrillary astrocytic neoplasms was examined by Kaplan-Meier survival analysis. Using a monoclonal antibody that reacts with both mutant and wild-type p53 protein (PAb 1801), reactivity was assessed immunohistochemically in specimens from the first diagnosis of astrocytic neoplasm in 95 patients: 26 astrocytomas (A), 19 anaplastic astrocytomas (AA). and 50 glioblastomas multiforme (GBM). Overall, 539c of cases exhibited any p53 nuclear immunoreactivity, with approximately the same proportion in each histologic grade. Survival was measured from diagnosis to death or last follow-up and ranged from 3 months to 9 years. Histologic grade was a powerful prognostic variable for this group of patients (p < 0.001), with median survivals of 88, 18, and 9 months for A, AA, and GBM patients, respectively. In contrast, patients with p53-immunoreactive or -nonimmunoreactive neoplasms had median survival times of 18 or 15 months, respectively (p = 0.21). These results indicate that p53 immunoreactivity was not prog-nostically significant in this group of adult patients with supratentorial fibrillary astrocytic neoplasms, although a small difference in survival cannot be excluded.
KW - Astrocytic neoplasms
KW - Immunohisto-chemistry
KW - Survival analysis
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U2 - 10.1097/00019606-199412000-00005
DO - 10.1097/00019606-199412000-00005
M3 - Article
C2 - 7866633
AN - SCOPUS:0027946403
SN - 1052-9551
VL - 3
SP - 240
EP - 245
JO - Diagnostic Molecular Pathology
JF - Diagnostic Molecular Pathology
IS - 4
ER -