Prognostic significance of large airway dimensions on computed tomography in the general population the multi-ethnic study of atherosclerosis (MESA) lung study

Elizabeth C. Oelsner, Benjamin M. Smith, Eric A. Hoffman, Ravi Kalhan, Kathleen M. Donohue, Joel D. Kaufman, Jennifer N. Nguyen, Ani W. Manichaikul, Jerome I. Rotter, Erin Donnelly Michos, David R. Jacobs, Gregory L. Burke, Aaron R. Folsom, Joseph E. Schwartz, Karol Watson, R. Graham Barr

Research output: Contribution to journalArticle

Abstract

Rationale: Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in chronic obstructive pulmonary disease (COPD), as well as with symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined. Objectives: To examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease. Methods: The Multi-Ethnic Study of Atherosclerosis recruited participants ages 45-84 years without cardiovascular disease in 2000-2002; we excluded participants with prevalent chronic lower respiratory disease (CLRD). Spirometry was measured in 2004-2006 and 2010-2012. CLRD hospitalizations and deaths were classified by validated criteria through 2014. The average wall thickness for a hypothetical airway of 10-mm lumen perimeter on CT (Pi10) was calculated using measures of airway wall thickness and lumen diameter. Models were adjusted for age, sex, principal components of ancestry, body mass index, smoking, pack-years, scanner, percent emphysema, genetic risk score, and initial forced expiratory volume in 1 second (FEV1) percent predicted. Results: Greater Pi10 was associated with 9% faster FEV1 decline (95% confidence interval [CI], 2 to 15%; P = 0.012) and increased incident COPD (odds ratio, 2.22; 95% CI, 1.43-3.45; P = 0.0004) per standard deviation among 1,830 participants. Over 78,147 person-years, higher Pi10 was associated with a 57% higher risk of first CLRD hospitalization or mortality (P = 0.0496) per standard deviation. Of Pi10's component measures, both greater airway wall thickness and narrower lumen predicted incident COPD and CLRD clinical events. Conclusions: In adults without CLRD, large airway dimensions on CT were prospectively associated with accelerated lung function decline and increased risks of COPD and CLRD hospitalization and mortality.

Original languageEnglish (US)
Pages (from-to)718-727
Number of pages10
JournalAnnals of the American Thoracic Society
Volume15
Issue number6
DOIs
StatePublished - Jun 1 2018

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Atherosclerosis
Tomography
Lung
Chronic Obstructive Pulmonary Disease
Population
Hospitalization
Spirometry
Forced Expiratory Volume
Lung Diseases
Confidence Intervals
Mortality
Body Mass Index
Cardiovascular Diseases
Smoking
Odds Ratio

Keywords

  • Chronic obstructive pulmonary disease
  • Computed tomography
  • Lung function
  • Risk stratification

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Prognostic significance of large airway dimensions on computed tomography in the general population the multi-ethnic study of atherosclerosis (MESA) lung study. / Oelsner, Elizabeth C.; Smith, Benjamin M.; Hoffman, Eric A.; Kalhan, Ravi; Donohue, Kathleen M.; Kaufman, Joel D.; Nguyen, Jennifer N.; Manichaikul, Ani W.; Rotter, Jerome I.; Michos, Erin Donnelly; Jacobs, David R.; Burke, Gregory L.; Folsom, Aaron R.; Schwartz, Joseph E.; Watson, Karol; Graham Barr, R.

In: Annals of the American Thoracic Society, Vol. 15, No. 6, 01.06.2018, p. 718-727.

Research output: Contribution to journalArticle

Oelsner, EC, Smith, BM, Hoffman, EA, Kalhan, R, Donohue, KM, Kaufman, JD, Nguyen, JN, Manichaikul, AW, Rotter, JI, Michos, ED, Jacobs, DR, Burke, GL, Folsom, AR, Schwartz, JE, Watson, K & Graham Barr, R 2018, 'Prognostic significance of large airway dimensions on computed tomography in the general population the multi-ethnic study of atherosclerosis (MESA) lung study', Annals of the American Thoracic Society, vol. 15, no. 6, pp. 718-727. https://doi.org/10.1513/AnnalsATS.201710-820OC
Oelsner, Elizabeth C. ; Smith, Benjamin M. ; Hoffman, Eric A. ; Kalhan, Ravi ; Donohue, Kathleen M. ; Kaufman, Joel D. ; Nguyen, Jennifer N. ; Manichaikul, Ani W. ; Rotter, Jerome I. ; Michos, Erin Donnelly ; Jacobs, David R. ; Burke, Gregory L. ; Folsom, Aaron R. ; Schwartz, Joseph E. ; Watson, Karol ; Graham Barr, R. / Prognostic significance of large airway dimensions on computed tomography in the general population the multi-ethnic study of atherosclerosis (MESA) lung study. In: Annals of the American Thoracic Society. 2018 ; Vol. 15, No. 6. pp. 718-727.
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abstract = "Rationale: Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in chronic obstructive pulmonary disease (COPD), as well as with symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined. Objectives: To examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease. Methods: The Multi-Ethnic Study of Atherosclerosis recruited participants ages 45-84 years without cardiovascular disease in 2000-2002; we excluded participants with prevalent chronic lower respiratory disease (CLRD). Spirometry was measured in 2004-2006 and 2010-2012. CLRD hospitalizations and deaths were classified by validated criteria through 2014. The average wall thickness for a hypothetical airway of 10-mm lumen perimeter on CT (Pi10) was calculated using measures of airway wall thickness and lumen diameter. Models were adjusted for age, sex, principal components of ancestry, body mass index, smoking, pack-years, scanner, percent emphysema, genetic risk score, and initial forced expiratory volume in 1 second (FEV1) percent predicted. Results: Greater Pi10 was associated with 9{\%} faster FEV1 decline (95{\%} confidence interval [CI], 2 to 15{\%}; P = 0.012) and increased incident COPD (odds ratio, 2.22; 95{\%} CI, 1.43-3.45; P = 0.0004) per standard deviation among 1,830 participants. Over 78,147 person-years, higher Pi10 was associated with a 57{\%} higher risk of first CLRD hospitalization or mortality (P = 0.0496) per standard deviation. Of Pi10's component measures, both greater airway wall thickness and narrower lumen predicted incident COPD and CLRD clinical events. Conclusions: In adults without CLRD, large airway dimensions on CT were prospectively associated with accelerated lung function decline and increased risks of COPD and CLRD hospitalization and mortality.",
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AU - Smith, Benjamin M.

AU - Hoffman, Eric A.

AU - Kalhan, Ravi

AU - Donohue, Kathleen M.

AU - Kaufman, Joel D.

AU - Nguyen, Jennifer N.

AU - Manichaikul, Ani W.

AU - Rotter, Jerome I.

AU - Michos, Erin Donnelly

AU - Jacobs, David R.

AU - Burke, Gregory L.

AU - Folsom, Aaron R.

AU - Schwartz, Joseph E.

AU - Watson, Karol

AU - Graham Barr, R.

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N2 - Rationale: Large airway dimensions on computed tomography (CT) have been associated with lung function, symptoms, and exacerbations in chronic obstructive pulmonary disease (COPD), as well as with symptoms in smokers with preserved spirometry. Their prognostic significance in persons without lung disease remains undefined. Objectives: To examine associations between large airway dimensions on CT and respiratory outcomes in a population-based cohort of adults without prevalent lung disease. Methods: The Multi-Ethnic Study of Atherosclerosis recruited participants ages 45-84 years without cardiovascular disease in 2000-2002; we excluded participants with prevalent chronic lower respiratory disease (CLRD). Spirometry was measured in 2004-2006 and 2010-2012. CLRD hospitalizations and deaths were classified by validated criteria through 2014. The average wall thickness for a hypothetical airway of 10-mm lumen perimeter on CT (Pi10) was calculated using measures of airway wall thickness and lumen diameter. Models were adjusted for age, sex, principal components of ancestry, body mass index, smoking, pack-years, scanner, percent emphysema, genetic risk score, and initial forced expiratory volume in 1 second (FEV1) percent predicted. Results: Greater Pi10 was associated with 9% faster FEV1 decline (95% confidence interval [CI], 2 to 15%; P = 0.012) and increased incident COPD (odds ratio, 2.22; 95% CI, 1.43-3.45; P = 0.0004) per standard deviation among 1,830 participants. Over 78,147 person-years, higher Pi10 was associated with a 57% higher risk of first CLRD hospitalization or mortality (P = 0.0496) per standard deviation. Of Pi10's component measures, both greater airway wall thickness and narrower lumen predicted incident COPD and CLRD clinical events. Conclusions: In adults without CLRD, large airway dimensions on CT were prospectively associated with accelerated lung function decline and increased risks of COPD and CLRD hospitalization and mortality.

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KW - Chronic obstructive pulmonary disease

KW - Computed tomography

KW - Lung function

KW - Risk stratification

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