Abstract
Objectives. To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy.Methods. Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were evaluated for biochemical recurrence (prostate-specific antigen progression) and distant metastases.Results. Eighty percent of patients had Gleason score 3+4, 20% had 4+3. The rate of established extraprostatic extension at radical prostatectomy for Gleason score 3+4 and 4+3 tumors was 38.2% and 52.7%, respectively (P = 0.008). With a mean follow-up of 4.6 years for men without progression, Gleason score 4+3 tumors had an increased risk of progression independent of stage and margin status (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 823-827 |
| Number of pages | 5 |
| Journal | Urology |
| Volume | 56 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2000 |
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ASJC Scopus subject areas
- Urology
Cite this
Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy. / Chan, Theresa Y.; Partin, Alan Wayne; Walsh, Patrick; Epstein, Jonathan Ira.
In: Urology, Vol. 56, No. 5, 2000, p. 823-827.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy
AU - Chan, Theresa Y.
AU - Partin, Alan Wayne
AU - Walsh, Patrick
AU - Epstein, Jonathan Ira
PY - 2000
Y1 - 2000
N2 - Objectives. To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy.Methods. Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were evaluated for biochemical recurrence (prostate-specific antigen progression) and distant metastases.Results. Eighty percent of patients had Gleason score 3+4, 20% had 4+3. The rate of established extraprostatic extension at radical prostatectomy for Gleason score 3+4 and 4+3 tumors was 38.2% and 52.7%, respectively (P = 0.008). With a mean follow-up of 4.6 years for men without progression, Gleason score 4+3 tumors had an increased risk of progression independent of stage and margin status (P
AB - Objectives. To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy.Methods. Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were evaluated for biochemical recurrence (prostate-specific antigen progression) and distant metastases.Results. Eighty percent of patients had Gleason score 3+4, 20% had 4+3. The rate of established extraprostatic extension at radical prostatectomy for Gleason score 3+4 and 4+3 tumors was 38.2% and 52.7%, respectively (P = 0.008). With a mean follow-up of 4.6 years for men without progression, Gleason score 4+3 tumors had an increased risk of progression independent of stage and margin status (P
UR - http://www.scopus.com/inward/record.url?scp=0033787042&partnerID=8YFLogxK
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U2 - 10.1016/S0090-4295(00)00753-6
DO - 10.1016/S0090-4295(00)00753-6
M3 - Article
C2 - 11068310
AN - SCOPUS:0033787042
VL - 56
SP - 823
EP - 827
JO - Urology
JF - Urology
SN - 0090-4295
IS - 5
ER -