Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy

Research output: Contribution to journalArticle

Abstract

Objectives. To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy.Methods. Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were evaluated for biochemical recurrence (prostate-specific antigen progression) and distant metastases.Results. Eighty percent of patients had Gleason score 3+4, 20% had 4+3. The rate of established extraprostatic extension at radical prostatectomy for Gleason score 3+4 and 4+3 tumors was 38.2% and 52.7%, respectively (P = 0.008). With a mean follow-up of 4.6 years for men without progression, Gleason score 4+3 tumors had an increased risk of progression independent of stage and margin status (P

Original languageEnglish (US)
Pages (from-to)823-827
Number of pages5
JournalUrology
Volume56
Issue number5
DOIs
StatePublished - 2000

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Neoplasm Grading
Prostatectomy
Neoplasms
Neoplasm Metastasis
Seminal Vesicles
Prostate-Specific Antigen
Lymph Nodes
Recurrence

ASJC Scopus subject areas

  • Urology

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Prognostic significance of Gleason score 3+4 versus Gleason score 4+3 tumor at radical prostatectomy. / Chan, Theresa Y.; Partin, Alan Wayne; Walsh, Patrick; Epstein, Jonathan Ira.

In: Urology, Vol. 56, No. 5, 2000, p. 823-827.

Research output: Contribution to journalArticle

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AU - Epstein, Jonathan Ira

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