Prognostic significance of colony-stimulating factor receptor expression in ipsilateral breast cancer recurrence

Mary Grey Maher, Eva Sapi, Bruce Turner, Andrew Gumbs, Peter L. Perrotta, Darryl Carter, Barry M. Kacinski, Bruce G. Haffty

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

The macrophage colony-stimulating factor receptor (CSF-1R), the product of the c-fms proto-oncogene, regulates normal proliferation and differentiation of macrophages and trophoblasts. Recent research found abnormal expression of CSF-1R in human carcinomas of the breast, endometrium, and ovary. Furthermore, activation of CSF-1R by its ligand has been shown to regulate invasiveness and anchorage-independent growth in breast carcinoma cells. To study the significance of CSF-1R expression in breast cancer, we designed a case-controlled immunohistochemical study. We chose 80 patients from a database of 1200 early stage I or II breast cancer patients treated with conservative surgery and radiation therapy. Expression of CSF-1R in the tumors of 40 patients who experienced an ipsilateral breast tumor recurrence (IBTR) as a primary site of relapse were compared with 40 patients who had not experienced an IBTR. The index and control patients were matched by age, clinical stage, nodal status, and follow-up. Paraffin-embedded sections were immunostained with anti-bodies directed toward CSF-1R. For the CSF-1R antibody, a total of 28 index cases (70%) demonstrated strong staining, whereas only 16 control cases (40%) demonstrated high immunoreactivity (P = 0.007). The CSF-1R antibody showed a positive correlation for local relapse, but no correlation was found between CSF-1R expression and distant metastasis. In summary, our findings provide evidence for the poor prognostic role of CSF-1R in IBTR.

Original languageEnglish (US)
Pages (from-to)1851-1856
Number of pages6
JournalClinical Cancer Research
Volume4
Issue number8
StatePublished - Aug 1998
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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