Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: A prospective study

H. Ogita, T. Shimonagata, M. Fukunami, K. Kumagai, T. Yamada, Y. Asano, A. Hirata, M. Asai, H. Kusuoka, M. Hori, N. Hoki

Research output: Contribution to journalArticle

Abstract

Objective - To determine whether cardiac iodine-123 metaiodobenzylguanidine (123I MIBG) imaging is useful in predicting the prognosis of patients with chronic heart failure. Design - Cardiac 123I MIBG imaging was done on entry to the study. The cardiac MIBG washout rate was calculated from anterior chest view images obtained 20 and 200 minutes after injection of the isotope. Study patients were divided into two groups with washout rates above and below 27% (the mean value + 2 SD obtained in 20 normal subjects), and were then followed up. Setting - Tertiary referral centre. Patients - 79 patients with chronic heart failure in whom the left ventricular ejection fraction was less than 40%. Results - There were 37 patients in group 1 (washout rate of ≥ 27%) and 42 in group 2 (<27%). During a follow up period of between 1 and 52 months, eight patients died suddenly and five died of worsening heart failure in group 1, while none died in group 2; 13 patients in group 1 and four in group 2 were admitted to hospital for progressive heart failure. Kaplan-Meier analysis showed that group 1 had a significantly higher mortality and morbidity (p = 0.001 and p <0.001, respectively) than group 2. Conclusions - Cardiac 123I MIBG washout rate seems to be a good predictor of prognosis in patients with chronic heart failure.

Original languageEnglish (US)
Pages (from-to)656-660
Number of pages5
JournalHeart
Volume86
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Heart Failure
Prospective Studies
3-Iodobenzylguanidine
Morbidity
Mortality
Kaplan-Meier Estimate
Tertiary Care Centers
Isotopes
Iodine
Stroke Volume
Thorax
Injections

Keywords

  • Cardiac adrenergic nerve activity
  • Chronic heart failure
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ogita, H., Shimonagata, T., Fukunami, M., Kumagai, K., Yamada, T., Asano, Y., ... Hoki, N. (2001). Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: A prospective study. Heart, 86(6), 656-660.

Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure : A prospective study. / Ogita, H.; Shimonagata, T.; Fukunami, M.; Kumagai, K.; Yamada, T.; Asano, Y.; Hirata, A.; Asai, M.; Kusuoka, H.; Hori, M.; Hoki, N.

In: Heart, Vol. 86, No. 6, 2001, p. 656-660.

Research output: Contribution to journalArticle

Ogita, H, Shimonagata, T, Fukunami, M, Kumagai, K, Yamada, T, Asano, Y, Hirata, A, Asai, M, Kusuoka, H, Hori, M & Hoki, N 2001, 'Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: A prospective study', Heart, vol. 86, no. 6, pp. 656-660.
Ogita, H. ; Shimonagata, T. ; Fukunami, M. ; Kumagai, K. ; Yamada, T. ; Asano, Y. ; Hirata, A. ; Asai, M. ; Kusuoka, H. ; Hori, M. ; Hoki, N. / Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure : A prospective study. In: Heart. 2001 ; Vol. 86, No. 6. pp. 656-660.
@article{aa614b4493814caaa08bea9ce2f60f1c,
title = "Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure: A prospective study",
abstract = "Objective - To determine whether cardiac iodine-123 metaiodobenzylguanidine (123I MIBG) imaging is useful in predicting the prognosis of patients with chronic heart failure. Design - Cardiac 123I MIBG imaging was done on entry to the study. The cardiac MIBG washout rate was calculated from anterior chest view images obtained 20 and 200 minutes after injection of the isotope. Study patients were divided into two groups with washout rates above and below 27{\%} (the mean value + 2 SD obtained in 20 normal subjects), and were then followed up. Setting - Tertiary referral centre. Patients - 79 patients with chronic heart failure in whom the left ventricular ejection fraction was less than 40{\%}. Results - There were 37 patients in group 1 (washout rate of ≥ 27{\%}) and 42 in group 2 (<27{\%}). During a follow up period of between 1 and 52 months, eight patients died suddenly and five died of worsening heart failure in group 1, while none died in group 2; 13 patients in group 1 and four in group 2 were admitted to hospital for progressive heart failure. Kaplan-Meier analysis showed that group 1 had a significantly higher mortality and morbidity (p = 0.001 and p <0.001, respectively) than group 2. Conclusions - Cardiac 123I MIBG washout rate seems to be a good predictor of prognosis in patients with chronic heart failure.",
keywords = "Cardiac adrenergic nerve activity, Chronic heart failure, Sudden death",
author = "H. Ogita and T. Shimonagata and M. Fukunami and K. Kumagai and T. Yamada and Y. Asano and A. Hirata and M. Asai and H. Kusuoka and M. Hori and N. Hoki",
year = "2001",
language = "English (US)",
volume = "86",
pages = "656--660",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "6",

}

TY - JOUR

T1 - Prognostic significance of cardiac 123I metaiodobenzylguanidine imaging for mortality and morbidity in patients with chronic heart failure

T2 - A prospective study

AU - Ogita, H.

AU - Shimonagata, T.

AU - Fukunami, M.

AU - Kumagai, K.

AU - Yamada, T.

AU - Asano, Y.

AU - Hirata, A.

AU - Asai, M.

AU - Kusuoka, H.

AU - Hori, M.

AU - Hoki, N.

PY - 2001

Y1 - 2001

N2 - Objective - To determine whether cardiac iodine-123 metaiodobenzylguanidine (123I MIBG) imaging is useful in predicting the prognosis of patients with chronic heart failure. Design - Cardiac 123I MIBG imaging was done on entry to the study. The cardiac MIBG washout rate was calculated from anterior chest view images obtained 20 and 200 minutes after injection of the isotope. Study patients were divided into two groups with washout rates above and below 27% (the mean value + 2 SD obtained in 20 normal subjects), and were then followed up. Setting - Tertiary referral centre. Patients - 79 patients with chronic heart failure in whom the left ventricular ejection fraction was less than 40%. Results - There were 37 patients in group 1 (washout rate of ≥ 27%) and 42 in group 2 (<27%). During a follow up period of between 1 and 52 months, eight patients died suddenly and five died of worsening heart failure in group 1, while none died in group 2; 13 patients in group 1 and four in group 2 were admitted to hospital for progressive heart failure. Kaplan-Meier analysis showed that group 1 had a significantly higher mortality and morbidity (p = 0.001 and p <0.001, respectively) than group 2. Conclusions - Cardiac 123I MIBG washout rate seems to be a good predictor of prognosis in patients with chronic heart failure.

AB - Objective - To determine whether cardiac iodine-123 metaiodobenzylguanidine (123I MIBG) imaging is useful in predicting the prognosis of patients with chronic heart failure. Design - Cardiac 123I MIBG imaging was done on entry to the study. The cardiac MIBG washout rate was calculated from anterior chest view images obtained 20 and 200 minutes after injection of the isotope. Study patients were divided into two groups with washout rates above and below 27% (the mean value + 2 SD obtained in 20 normal subjects), and were then followed up. Setting - Tertiary referral centre. Patients - 79 patients with chronic heart failure in whom the left ventricular ejection fraction was less than 40%. Results - There were 37 patients in group 1 (washout rate of ≥ 27%) and 42 in group 2 (<27%). During a follow up period of between 1 and 52 months, eight patients died suddenly and five died of worsening heart failure in group 1, while none died in group 2; 13 patients in group 1 and four in group 2 were admitted to hospital for progressive heart failure. Kaplan-Meier analysis showed that group 1 had a significantly higher mortality and morbidity (p = 0.001 and p <0.001, respectively) than group 2. Conclusions - Cardiac 123I MIBG washout rate seems to be a good predictor of prognosis in patients with chronic heart failure.

KW - Cardiac adrenergic nerve activity

KW - Chronic heart failure

KW - Sudden death

UR - http://www.scopus.com/inward/record.url?scp=0035180535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035180535&partnerID=8YFLogxK

M3 - Article

C2 - 11711461

AN - SCOPUS:0035180535

VL - 86

SP - 656

EP - 660

JO - Heart

JF - Heart

SN - 1355-6037

IS - 6

ER -