Abstract
This study aims at clarifying the prognostic role of high-grade tumor budding (TB) in pancreatic ductal adenocarcinoma (PDAC) with the first systematic review and meta-analysis on this topic. Furthermore, we analyzed with a systematic review the relationship between TB and a recently suggested TB-associated mechanism: the epithelial to mesenchymal transition (EMT). Analyzing a total of 613 patients, 251 of them (40.9%) with high grade-TB, we found an increased risk of all-cause mortality (RR, 1.46; 95% CI, 1.13-1.88, p = 0.004; HR, 2.65; 95% CI, 1.79-3.91; p < 0.0001) and of recurrence (RR, 1.61; 95% CI, 1.05-2.47, p = 0.03) for PDAC patients with high-grade TB. Moreover, we found that EMT is a central process in determining the presence of TB in PDAC. Thanks to this meta-analysis, we demonstrate the potential clinical significance of high-grade TB for prognostic stratification of PDAC. TB also shows a clear association with the process of EMT. Based on the results of the present study, TB should be conveyed in pathology reports and taken into account by future oncologic staging systems.
| Original language | English (US) |
|---|---|
| Article number | 113 |
| Journal | Cancers |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Budding
- Buds
- EMT
- Epithelial to mesenchymal transition
- Pancreatic cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Prognostic role of high-grade tumor budding in pancreatic ductal adenocarcinoma : A systematic review and meta-analysis with a focus on epithelial to mesenchymal transition. / Lawlor, Rita T.; Veronese, Nicola; Nottegar, Alessia; Malleo, Giuseppe; Smith, Lee; Demurtas, Jacopo; Cheng, Liang; Wood, Laura Delong; Silvestris, Nicola; Salvia, Roberto; Scarpa, Aldo; Luchini, Claudio.
In: Cancers, Vol. 11, No. 1, 113, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Prognostic role of high-grade tumor budding in pancreatic ductal adenocarcinoma
T2 - A systematic review and meta-analysis with a focus on epithelial to mesenchymal transition
AU - Lawlor, Rita T.
AU - Veronese, Nicola
AU - Nottegar, Alessia
AU - Malleo, Giuseppe
AU - Smith, Lee
AU - Demurtas, Jacopo
AU - Cheng, Liang
AU - Wood, Laura Delong
AU - Silvestris, Nicola
AU - Salvia, Roberto
AU - Scarpa, Aldo
AU - Luchini, Claudio
PY - 2019/1/1
Y1 - 2019/1/1
N2 - This study aims at clarifying the prognostic role of high-grade tumor budding (TB) in pancreatic ductal adenocarcinoma (PDAC) with the first systematic review and meta-analysis on this topic. Furthermore, we analyzed with a systematic review the relationship between TB and a recently suggested TB-associated mechanism: the epithelial to mesenchymal transition (EMT). Analyzing a total of 613 patients, 251 of them (40.9%) with high grade-TB, we found an increased risk of all-cause mortality (RR, 1.46; 95% CI, 1.13-1.88, p = 0.004; HR, 2.65; 95% CI, 1.79-3.91; p < 0.0001) and of recurrence (RR, 1.61; 95% CI, 1.05-2.47, p = 0.03) for PDAC patients with high-grade TB. Moreover, we found that EMT is a central process in determining the presence of TB in PDAC. Thanks to this meta-analysis, we demonstrate the potential clinical significance of high-grade TB for prognostic stratification of PDAC. TB also shows a clear association with the process of EMT. Based on the results of the present study, TB should be conveyed in pathology reports and taken into account by future oncologic staging systems.
AB - This study aims at clarifying the prognostic role of high-grade tumor budding (TB) in pancreatic ductal adenocarcinoma (PDAC) with the first systematic review and meta-analysis on this topic. Furthermore, we analyzed with a systematic review the relationship between TB and a recently suggested TB-associated mechanism: the epithelial to mesenchymal transition (EMT). Analyzing a total of 613 patients, 251 of them (40.9%) with high grade-TB, we found an increased risk of all-cause mortality (RR, 1.46; 95% CI, 1.13-1.88, p = 0.004; HR, 2.65; 95% CI, 1.79-3.91; p < 0.0001) and of recurrence (RR, 1.61; 95% CI, 1.05-2.47, p = 0.03) for PDAC patients with high-grade TB. Moreover, we found that EMT is a central process in determining the presence of TB in PDAC. Thanks to this meta-analysis, we demonstrate the potential clinical significance of high-grade TB for prognostic stratification of PDAC. TB also shows a clear association with the process of EMT. Based on the results of the present study, TB should be conveyed in pathology reports and taken into account by future oncologic staging systems.
KW - Budding
KW - Buds
KW - EMT
KW - Epithelial to mesenchymal transition
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=85061985339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061985339&partnerID=8YFLogxK
U2 - 10.3390/cancers11010113
DO - 10.3390/cancers11010113
M3 - Review article
C2 - 30669452
AN - SCOPUS:85061985339
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 1
M1 - 113
ER -