Abstract
A cohort of 544 human immunodeficiency virus-1 (HIV-1) seropositive intravenous drug users (IVDUs) was recruited in 1988 and early 1989; data on laboratory markers, clinical symptoms, intravenous drug use, and demographics were collected. Forty-one IVDUs developed AIDS within 2 years of enrollment. Data were analyzed using methods of survival analysis. None of the individuals reported use of antiviral agents or Pneumocystis carinii prophylaxis at baseline. A very strong (p 12 nmol/L showed significant associations with the relative hazard (95% confidence interval) of AIDS after controlling for CD4 of 2.9 (1.6, 5.6) and 2.0 (1.0, 3.7), respectively. In these IVDUs, serum β2-microglobulin did not add predictive power for progression to AIDS. The effect of clinical symptoms was stronger for high CD4 cell counts, indicating the need to monitor HIV seropositive IVDUs with both laboratory studies and clinical evaluation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 694-700 |
| Number of pages | 7 |
| Journal | Journal of Acquired Immune Deficiency Syndromes |
| Volume | 5 |
| Issue number | 7 |
| State | Published - 1992 |
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Keywords
- Cohort studies
- Immunological markers
- Intravenous drug users
- Life-table regression
- Prognosis
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)
- Virology
- Immunology and Allergy
Cite this
Prognostic indicators for development of aids among intravenous drug users. / Munoz, Alvaro; Vlahov, David; Solomon, Liza; Margolick, Joseph Bernard; Bareta, J. C.; Cohn, Sylvia; Astemborski, Jacquie; Nelson, Kenrad Edwin.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 5, No. 7, 1992, p. 694-700.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic indicators for development of aids among intravenous drug users
AU - Munoz, Alvaro
AU - Vlahov, David
AU - Solomon, Liza
AU - Margolick, Joseph Bernard
AU - Bareta, J. C.
AU - Cohn, Sylvia
AU - Astemborski, Jacquie
AU - Nelson, Kenrad Edwin
PY - 1992
Y1 - 1992
N2 - A cohort of 544 human immunodeficiency virus-1 (HIV-1) seropositive intravenous drug users (IVDUs) was recruited in 1988 and early 1989; data on laboratory markers, clinical symptoms, intravenous drug use, and demographics were collected. Forty-one IVDUs developed AIDS within 2 years of enrollment. Data were analyzed using methods of survival analysis. None of the individuals reported use of antiviral agents or Pneumocystis carinii prophylaxis at baseline. A very strong (p 12 nmol/L showed significant associations with the relative hazard (95% confidence interval) of AIDS after controlling for CD4 of 2.9 (1.6, 5.6) and 2.0 (1.0, 3.7), respectively. In these IVDUs, serum β2-microglobulin did not add predictive power for progression to AIDS. The effect of clinical symptoms was stronger for high CD4 cell counts, indicating the need to monitor HIV seropositive IVDUs with both laboratory studies and clinical evaluation.
AB - A cohort of 544 human immunodeficiency virus-1 (HIV-1) seropositive intravenous drug users (IVDUs) was recruited in 1988 and early 1989; data on laboratory markers, clinical symptoms, intravenous drug use, and demographics were collected. Forty-one IVDUs developed AIDS within 2 years of enrollment. Data were analyzed using methods of survival analysis. None of the individuals reported use of antiviral agents or Pneumocystis carinii prophylaxis at baseline. A very strong (p 12 nmol/L showed significant associations with the relative hazard (95% confidence interval) of AIDS after controlling for CD4 of 2.9 (1.6, 5.6) and 2.0 (1.0, 3.7), respectively. In these IVDUs, serum β2-microglobulin did not add predictive power for progression to AIDS. The effect of clinical symptoms was stronger for high CD4 cell counts, indicating the need to monitor HIV seropositive IVDUs with both laboratory studies and clinical evaluation.
KW - Cohort studies
KW - Immunological markers
KW - Intravenous drug users
KW - Life-table regression
KW - Prognosis
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UR - http://www.scopus.com/inward/citedby.url?scp=0026635362&partnerID=8YFLogxK
M3 - Article
C2 - 1613668
AN - SCOPUS:0026635362
VL - 5
SP - 694
EP - 700
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
SN - 1525-4135
IS - 7
ER -