Prognostic indicators for development of aids among intravenous drug users

Alvaro Munoz, David Vlahov, Liza Solomon, Joseph Bernard Margolick, J. C. Bareta, Sylvia Cohn, Jacquie Astemborski, Kenrad Edwin Nelson

Research output: Contribution to journalArticle

Abstract

A cohort of 544 human immunodeficiency virus-1 (HIV-1) seropositive intravenous drug users (IVDUs) was recruited in 1988 and early 1989; data on laboratory markers, clinical symptoms, intravenous drug use, and demographics were collected. Forty-one IVDUs developed AIDS within 2 years of enrollment. Data were analyzed using methods of survival analysis. None of the individuals reported use of antiviral agents or Pneumocystis carinii prophylaxis at baseline. A very strong (p 12 nmol/L showed significant associations with the relative hazard (95% confidence interval) of AIDS after controlling for CD4 of 2.9 (1.6, 5.6) and 2.0 (1.0, 3.7), respectively. In these IVDUs, serum β2-microglobulin did not add predictive power for progression to AIDS. The effect of clinical symptoms was stronger for high CD4 cell counts, indicating the need to monitor HIV seropositive IVDUs with both laboratory studies and clinical evaluation.

Original languageEnglish (US)
Pages (from-to)694-700
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume5
Issue number7
StatePublished - 1992

Fingerprint

Drug Users
Acquired Immunodeficiency Syndrome
Pneumocystis carinii
CD4 Lymphocyte Count
Survival Analysis
Antiviral Agents
HIV-1
Biomarkers
Demography
HIV
Confidence Intervals
Serum
Pharmaceutical Preparations

Keywords

  • Cohort studies
  • Immunological markers
  • Intravenous drug users
  • Life-table regression
  • Prognosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Virology
  • Immunology and Allergy

Cite this

Prognostic indicators for development of aids among intravenous drug users. / Munoz, Alvaro; Vlahov, David; Solomon, Liza; Margolick, Joseph Bernard; Bareta, J. C.; Cohn, Sylvia; Astemborski, Jacquie; Nelson, Kenrad Edwin.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 5, No. 7, 1992, p. 694-700.

Research output: Contribution to journalArticle

Munoz, Alvaro ; Vlahov, David ; Solomon, Liza ; Margolick, Joseph Bernard ; Bareta, J. C. ; Cohn, Sylvia ; Astemborski, Jacquie ; Nelson, Kenrad Edwin. / Prognostic indicators for development of aids among intravenous drug users. In: Journal of Acquired Immune Deficiency Syndromes. 1992 ; Vol. 5, No. 7. pp. 694-700.
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