Prognostic implication and characterization of the blast cell population in the myelodysplastic syndrome

Jean Etienne Goasguen; John M. Bennett; Christopher Cox; Henry Hambley; Ghulam Mufti; Georges Flandrin

doi:10.1016/0145-2126(91)90185-V

Prognostic implication and characterization of the blast cell population in the myelodysplastic syndrome

Jean Etienne Goasguen, John M. Bennett, Christopher Cox, Henry Hambley, Ghulam Mufti, Georges Flandrin

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The bone marrow smears of 18 confirmed cases of MDS were analyzed carefully for the presence of "hypergranular type III blasts", defined as more than 20 fine azurophil primary granules per cells. The concordance was close to 80% among 5 observers. Thirty-nine percent (7 cases) were reclassified as RAEB-t rather than RAEB. The presence of these hypergranular blasts was not suggestive of increased differentiation but rather leukemic cells. The reassignment of cases altered the median survival for the various subcategories, providing a clearer separation with the introduction of type III blasts than without utilizing these cells which were separated from the promyelocyte family. The introduction of this new blast cell definition in a larger series of patients is recommended to confirm these preliminary observations.

Original language	English (US)
Pages (from-to)	1159-1161,1163-1165
Journal	Leukemia Research
Volume	15
Issue number	12
DOIs	https://doi.org/10.1016/0145-2126(91)90185-V
State	Published - 1991
Externally published	Yes

Keywords

Myelodysplastic syndrome
blast cells
prognostic factor

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/0145-2126(91)90185-V

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title = "Prognostic implication and characterization of the blast cell population in the myelodysplastic syndrome",

abstract = "The bone marrow smears of 18 confirmed cases of MDS were analyzed carefully for the presence of {"}hypergranular type III blasts{"}, defined as more than 20 fine azurophil primary granules per cells. The concordance was close to 80% among 5 observers. Thirty-nine percent (7 cases) were reclassified as RAEB-t rather than RAEB. The presence of these hypergranular blasts was not suggestive of increased differentiation but rather leukemic cells. The reassignment of cases altered the median survival for the various subcategories, providing a clearer separation with the introduction of type III blasts than without utilizing these cells which were separated from the promyelocyte family. The introduction of this new blast cell definition in a larger series of patients is recommended to confirm these preliminary observations.",

keywords = "Myelodysplastic syndrome, blast cells, prognostic factor",

author = "Goasguen, {Jean Etienne} and Bennett, {John M.} and Christopher Cox and Henry Hambley and Ghulam Mufti and Georges Flandrin",

note = "Funding Information: The percentage of blasts may be the single most important prognostic factor both in terms of overall survival as well as leukemic transformation. The FAB classification recognizes ~hree groups of patients according to the percentage of blasts: cases with less than 5~ blasts, cases with 5-20c~ blasts and patients Supported by grants from Association pour la recherche sur le Cancer: ARC. France, Fondation Langlois, France, grants CA-11083 and CAd 1198 from the National Cancer Institute, NIII. U.S.A.",

year = "1991",

doi = "10.1016/0145-2126(91)90185-V",

language = "English (US)",

volume = "15",

pages = "1159--1161,1163--1165",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Limited",

number = "12",

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T1 - Prognostic implication and characterization of the blast cell population in the myelodysplastic syndrome

AU - Goasguen, Jean Etienne

AU - Bennett, John M.

AU - Cox, Christopher

AU - Hambley, Henry

AU - Mufti, Ghulam

AU - Flandrin, Georges

N1 - Funding Information: The percentage of blasts may be the single most important prognostic factor both in terms of overall survival as well as leukemic transformation. The FAB classification recognizes ~hree groups of patients according to the percentage of blasts: cases with less than 5~ blasts, cases with 5-20c~ blasts and patients Supported by grants from Association pour la recherche sur le Cancer: ARC. France, Fondation Langlois, France, grants CA-11083 and CAd 1198 from the National Cancer Institute, NIII. U.S.A.

PY - 1991

Y1 - 1991

N2 - The bone marrow smears of 18 confirmed cases of MDS were analyzed carefully for the presence of "hypergranular type III blasts", defined as more than 20 fine azurophil primary granules per cells. The concordance was close to 80% among 5 observers. Thirty-nine percent (7 cases) were reclassified as RAEB-t rather than RAEB. The presence of these hypergranular blasts was not suggestive of increased differentiation but rather leukemic cells. The reassignment of cases altered the median survival for the various subcategories, providing a clearer separation with the introduction of type III blasts than without utilizing these cells which were separated from the promyelocyte family. The introduction of this new blast cell definition in a larger series of patients is recommended to confirm these preliminary observations.

AB - The bone marrow smears of 18 confirmed cases of MDS were analyzed carefully for the presence of "hypergranular type III blasts", defined as more than 20 fine azurophil primary granules per cells. The concordance was close to 80% among 5 observers. Thirty-nine percent (7 cases) were reclassified as RAEB-t rather than RAEB. The presence of these hypergranular blasts was not suggestive of increased differentiation but rather leukemic cells. The reassignment of cases altered the median survival for the various subcategories, providing a clearer separation with the introduction of type III blasts than without utilizing these cells which were separated from the promyelocyte family. The introduction of this new blast cell definition in a larger series of patients is recommended to confirm these preliminary observations.

KW - Myelodysplastic syndrome

KW - blast cells

KW - prognostic factor

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Prognostic implication and characterization of the blast cell population in the myelodysplastic syndrome

Abstract

Keywords

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