Prognostic factors in melanoma outcome and survival

Thong T. Le, Karen Pitman

Research output: Contribution to journalReview article

Abstract

Several clinicopathological factors have been identified as influencing outcome and survival in patients with CMM. The most important prognostic determinants in localized disease are the tumor thickness and the presence of ulceration. In the subgroup of thin tumors (< 1.0 mm), the level of invasion represents the most important prognosticator. In regional disease, the most significant independent predictors of survival are the number of metastatic nodes, the nodal tumor burden, and the presence of ulceration. In distant disease, the most important independent prognosticators are the site of metastatic involvement, the serum LDH level, and the number of metastases. Accordingly, the 2002 AJCC melanoma staging system represents an incorporation of the most recent prognostic data. In the future, further advances in diagnostic and staging techniques (eg, imaging and molecular staging) will undoubtedly lead to new and more accurate prognostic information.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalFacial Plastic Surgery Clinics of North America
Volume11
Issue number1
DOIs
StatePublished - Feb 2003
Externally publishedYes

Fingerprint

Melanoma
Survival
Molecular Imaging
Tumor Burden
Neoplasms
Neoplasm Metastasis
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Prognostic factors in melanoma outcome and survival. / Le, Thong T.; Pitman, Karen.

In: Facial Plastic Surgery Clinics of North America, Vol. 11, No. 1, 02.2003, p. 33-41.

Research output: Contribution to journalReview article

@article{2feb07790c8843908efd13170294af6c,
title = "Prognostic factors in melanoma outcome and survival",
abstract = "Several clinicopathological factors have been identified as influencing outcome and survival in patients with CMM. The most important prognostic determinants in localized disease are the tumor thickness and the presence of ulceration. In the subgroup of thin tumors (< 1.0 mm), the level of invasion represents the most important prognosticator. In regional disease, the most significant independent predictors of survival are the number of metastatic nodes, the nodal tumor burden, and the presence of ulceration. In distant disease, the most important independent prognosticators are the site of metastatic involvement, the serum LDH level, and the number of metastases. Accordingly, the 2002 AJCC melanoma staging system represents an incorporation of the most recent prognostic data. In the future, further advances in diagnostic and staging techniques (eg, imaging and molecular staging) will undoubtedly lead to new and more accurate prognostic information.",
author = "Le, {Thong T.} and Karen Pitman",
year = "2003",
month = "2",
doi = "10.1016/S1064-7406(02)00058-5",
language = "English (US)",
volume = "11",
pages = "33--41",
journal = "Facial Plastic Surgery Clinics of North America",
issn = "1064-7406",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Prognostic factors in melanoma outcome and survival

AU - Le, Thong T.

AU - Pitman, Karen

PY - 2003/2

Y1 - 2003/2

N2 - Several clinicopathological factors have been identified as influencing outcome and survival in patients with CMM. The most important prognostic determinants in localized disease are the tumor thickness and the presence of ulceration. In the subgroup of thin tumors (< 1.0 mm), the level of invasion represents the most important prognosticator. In regional disease, the most significant independent predictors of survival are the number of metastatic nodes, the nodal tumor burden, and the presence of ulceration. In distant disease, the most important independent prognosticators are the site of metastatic involvement, the serum LDH level, and the number of metastases. Accordingly, the 2002 AJCC melanoma staging system represents an incorporation of the most recent prognostic data. In the future, further advances in diagnostic and staging techniques (eg, imaging and molecular staging) will undoubtedly lead to new and more accurate prognostic information.

AB - Several clinicopathological factors have been identified as influencing outcome and survival in patients with CMM. The most important prognostic determinants in localized disease are the tumor thickness and the presence of ulceration. In the subgroup of thin tumors (< 1.0 mm), the level of invasion represents the most important prognosticator. In regional disease, the most significant independent predictors of survival are the number of metastatic nodes, the nodal tumor burden, and the presence of ulceration. In distant disease, the most important independent prognosticators are the site of metastatic involvement, the serum LDH level, and the number of metastases. Accordingly, the 2002 AJCC melanoma staging system represents an incorporation of the most recent prognostic data. In the future, further advances in diagnostic and staging techniques (eg, imaging and molecular staging) will undoubtedly lead to new and more accurate prognostic information.

UR - http://www.scopus.com/inward/record.url?scp=0038544698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038544698&partnerID=8YFLogxK

U2 - 10.1016/S1064-7406(02)00058-5

DO - 10.1016/S1064-7406(02)00058-5

M3 - Review article

C2 - 15062285

AN - SCOPUS:0038544698

VL - 11

SP - 33

EP - 41

JO - Facial Plastic Surgery Clinics of North America

JF - Facial Plastic Surgery Clinics of North America

SN - 1064-7406

IS - 1

ER -