Prognostic factors for stage i ovarian carcinoma

Jeffrey D. Seidman, Anna V. Yemelyanova, Fatemeh Khedmati, Michael A. Bidus, Louis Dainty, Charles R. Boice, Jonathan A. Cosin

Research output: Contribution to journalArticle

Abstract

Stage I ovarian carcinoma is relatively uncommon, and data on prognostic factors are conflicting. The clinical and pathologic features of 51 International Federation of Gynecology and Obstetrics stage I ovarian carcinomas were analyzed. There were 22 stage IA, 1 stage IB, and 28 stage IC cases. The mean follow-up was 6.1 years. The 5-year and 10-year disease-specific survival rates for the entire cohort were 92% and 78%, respectively. Among 51 patients, there were 6 tumor deaths, and 1 patient died of unrelated causes. All patients who died of disease were stage IC. Significant adverse prognostic factors were serous histology [relative risk (RR) 5.4, 95% confidence interval (CI) 1.3-22.0] and stage IC (RR 1.3, 95% CI 1.1-1.5). Among factors associated with stage IC, only positive washings or ascites affected survival (RR 9.25, 95% CI 1.9-44.4). The 5-year survival rates for stages IA and IC were 100% and 83%, respectively (P<0.025, log rank test). For comprehensively staged patients, the 5-year survival rate was 96% as compared with 72% for all others (P<0.025, log rank test). Tumor rupture, surface involvement, histologic grade and clear cell histology were not of adverse prognostic significance. Serous histology and positive washings or ascites are adverse prognostic factors in stage I. The prognostic importance of tumor grade, rupture, surface involvement and clear cell histology remains unclear. Patients who are International Federation of Gynecology and Obstetrics stage I on the basis of comprehensive surgical staging have an excellent prognosis.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Clear cell carcinoma
  • FIGO stage
  • Grade
  • Ovarian carcinoma
  • Prognosis
  • Serous carcinoma
  • Staging
  • Tumor rupture

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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  • Cite this

    Seidman, J. D., Yemelyanova, A. V., Khedmati, F., Bidus, M. A., Dainty, L., Boice, C. R., & Cosin, J. A. (2010). Prognostic factors for stage i ovarian carcinoma. International Journal of Gynecological Pathology, 29(1), 1-7. https://doi.org/10.1097/PGP.0b013e3181af2372