Prognostic factors following enucleation of 1 1 1 uveal melanomas

Kate Coleman; Jan P.A. Baak; Paul Van Diest; Joan Mullaney; Michael Farrell; Maurice Fenton

doi:10.1136/bjo.77.11.688

Prognostic factors following enucleation of 1 1 1 uveal melanomas

Kate Coleman, Jan P.A. Baak, Paul Van Diest, Joan Mullaney, Michael Farrell, Maurice Fenton

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate analysis isolated each of the following as significant prognosticators: largest tumour diameter (LTD) (p<0002), presence of epithelioid cells (p<0-03), and glaucoma (p<O0OO1). A combination of cell type, glaucoma, and LTD (p<00001) had strong and independent prognostic significance in multivanate analysis. The results of this series are compared with previous studies and the value of cell type information and new quantitative parameters is discussed.

Original language	English (US)
Pages (from-to)	688-692
Number of pages	5
Journal	British Journal of Ophthalmology
Volume	77
Issue number	11
DOIs	https://doi.org/10.1136/bjo.77.11.688
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.1136/bjo.77.11.688

Cite this

@article{842167e28be045899f33b94e1b5217f0,

title = "Prognostic factors following enucleation of 1 1 1 uveal melanomas",

abstract = "Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate analysis isolated each of the following as significant prognosticators: largest tumour diameter (LTD) (p<0002), presence of epithelioid cells (p<0-03), and glaucoma (p<O0OO1). A combination of cell type, glaucoma, and LTD (p<00001) had strong and independent prognostic significance in multivanate analysis. The results of this series are compared with previous studies and the value of cell type information and new quantitative parameters is discussed.",

author = "Kate Coleman and Baak, {Jan P.A.} and {Van Diest}, Paul and Joan Mullaney and Michael Farrell and Maurice Fenton",

year = "1993",

doi = "10.1136/bjo.77.11.688",

language = "English (US)",

volume = "77",

pages = "688--692",

journal = "British Journal of Ophthalmology",

issn = "0007-1161",

publisher = "BMJ Publishing Group",

number = "11",

}

TY - JOUR

T1 - Prognostic factors following enucleation of 1 1 1 uveal melanomas

AU - Coleman, Kate

AU - Baak, Jan P.A.

AU - Van Diest, Paul

AU - Mullaney, Joan

AU - Farrell, Michael

AU - Fenton, Maurice

PY - 1993

Y1 - 1993

N2 - Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate analysis isolated each of the following as significant prognosticators: largest tumour diameter (LTD) (p<0002), presence of epithelioid cells (p<0-03), and glaucoma (p<O0OO1). A combination of cell type, glaucoma, and LTD (p<00001) had strong and independent prognostic significance in multivanate analysis. The results of this series are compared with previous studies and the value of cell type information and new quantitative parameters is discussed.

AB - Follow up information was retrieved on 111 patients who underwent enucleation for uveal melanoma between 1964 and 1987, allowing a minimum postoperative period of 5 years. Univariate survival analysis was carried out using Kaplan-Meier curves and the differences between the curves were analysed with the Mantel-Cox test. Multivariate analysis used the Cox proportional hazards model. Univariate analysis isolated each of the following as significant prognosticators: largest tumour diameter (LTD) (p<0002), presence of epithelioid cells (p<0-03), and glaucoma (p<O0OO1). A combination of cell type, glaucoma, and LTD (p<00001) had strong and independent prognostic significance in multivanate analysis. The results of this series are compared with previous studies and the value of cell type information and new quantitative parameters is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0027436623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027436623&partnerID=8YFLogxK

U2 - 10.1136/bjo.77.11.688

DO - 10.1136/bjo.77.11.688

M3 - Article

C2 - 8280680

AN - SCOPUS:0027436623

SN - 0007-1161

VL - 77

SP - 688

EP - 692

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 11

ER -

Prognostic factors following enucleation of 1 1 1 uveal melanomas

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this