Prognostic factors and risk stratification in early mycosis fungoides

Eric C. Vonderheid, Igor Pavlov, Julio C. Delgado, Thomas B. Martins, Gladys H. Telang, Allan D. Hess, Marshall E. Kadin

Research output: Contribution to journalArticle

Abstract

Available demographic, clinical, histologic, immunohistochemical and laboratory findings, including serum cytokine/cytokine receptor levels, obtained at initial evaluation in a cohort of 33 patients with mycosis fungoides (MF) at stages I-IIA who had subsequent progression of disease were compared against 70 stage-matched cases of MF without observed progression. Significant factors that correlated with both disease progression and overall survival were: (1) presence of large Pautrier microabscesses (10 or more atypical lymphocytes), (2) presence of atypical lymphocytes with hyperchromatic or vesicular nuclei in the dermal infiltrate, (3) less than 20% CD8 + cells in the dermal infiltrate and (4) above normal (> 122 U/mL) serum immunoglobulin E (IgE) level. Combination of these factors was used to construct prognostic groupings which, if validated, might be useful to identify patients with clinically early MF at highest risk for disease progression and poor outcome.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalLeukemia and Lymphoma
Volume55
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cytokine production
  • Lymphoma and Hodgkin disease
  • Prognostication
  • T-cell mediated immunity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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  • Cite this

    Vonderheid, E. C., Pavlov, I., Delgado, J. C., Martins, T. B., Telang, G. H., Hess, A. D., & Kadin, M. E. (2014). Prognostic factors and risk stratification in early mycosis fungoides. Leukemia and Lymphoma, 55(1), 44-50. https://doi.org/10.3109/10428194.2013.790541