Prognostic biomarkers for HNSCC using quantitative real-time PCR and microarray analysis: β-tubulin isotypes and the p53 interactome

Sharon Lobert, Mary E. Graichen, Robert D. Hamilton, Karen T. Pitman, Michael R. Garrett, Chindo Hicks, Tejaswi Koganti

Research output: Contribution to journalArticle

Abstract

In 2014, more than 40,000 people in the United States will be diagnosed with head and neck squamous cell cancer (HNSCC) and nearly 8400 people will die of the disease (www.cancer.org/acs/groups). Little is known regarding molecular targets that might lead to better therapies and improved outcomes for these patients. The incorporation of taxanes into the standard cisplatin/5-fluouracil initial chemotherapy for HNSCC has been associated with improved response rate and survival. Taxanes target the β-subunit of the tubulin heterodimers, the major protein in microtubules, and halt cell division at G2/M phase. Both laboratory and clinical research suggest a link between β-tubulin expression and cancer patient survival, indicating that patterns of expression for β-tubulin isotypes along with activity of tumor suppressors such as p53 or micro-RNAs could be useful prognostic biomarkers and could suggest therapeutic targets.

Original languageEnglish (US)
Pages (from-to)628-637
Number of pages10
JournalCytoskeleton
Volume71
Issue number11
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • HNSCC
  • P53
  • TUBB3
  • Tubulin
  • Tubulin isotypes

ASJC Scopus subject areas

  • Structural Biology
  • Cell Biology

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