Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma

Mohammed Tanjimur Rahman, Kentaro Nakayama, Munmun Rahman, Naomi Nakayama, Masako Ishikawa, Atsuko Katagiri, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Ie Ming Shih, Kohji Miyazaki

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The goal of this study was to examine the clinical significance of ZNF217 amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian clear cell carcinoma (OCCC). METHODS: ZNF217 expression and amplification in OCCC was assessed by immunohistochemistry, fluorescence in situ hybridization, and clinical data collected via a retrospective chart review. ZNF217 gene knockdown using silencing RNA (siRNA) was used to assess ZNF217 functions in OCCC cell lines. RESULTS: Gene amplification was identified in 12 of 60 (20.0%) OCCCs. ZNF217 copy number correlated significantly with ZNF217 protein expression (r = 0.341; P

Original languageEnglish (US)
Pages (from-to)2846-2857
Number of pages12
JournalCancer
Volume118
Issue number11
DOIs
StatePublished - Jun 1 2012

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Chromosomes
Carcinoma
Gene Knockdown Techniques
Gene Amplification
RNA Interference
Fluorescence In Situ Hybridization
Therapeutics
Immunohistochemistry
Cell Line
Proteins

Keywords

  • fluorescence in situ hybridization
  • gene amplification
  • ovarian clear cell carcinoma
  • potential therapeutic target
  • survival
  • ZNF217

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Rahman, M. T., Nakayama, K., Rahman, M., Nakayama, N., Ishikawa, M., Katagiri, A., ... Miyazaki, K. (2012). Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma. Cancer, 118(11), 2846-2857. https://doi.org/10.1002/cncr.26598

Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma. / Rahman, Mohammed Tanjimur; Nakayama, Kentaro; Rahman, Munmun; Nakayama, Naomi; Ishikawa, Masako; Katagiri, Atsuko; Iida, Kouji; Nakayama, Satoru; Otsuki, Yoshiro; Shih, Ie Ming; Miyazaki, Kohji.

In: Cancer, Vol. 118, No. 11, 01.06.2012, p. 2846-2857.

Research output: Contribution to journalArticle

Rahman, MT, Nakayama, K, Rahman, M, Nakayama, N, Ishikawa, M, Katagiri, A, Iida, K, Nakayama, S, Otsuki, Y, Shih, IM & Miyazaki, K 2012, 'Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma', Cancer, vol. 118, no. 11, pp. 2846-2857. https://doi.org/10.1002/cncr.26598
Rahman MT, Nakayama K, Rahman M, Nakayama N, Ishikawa M, Katagiri A et al. Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma. Cancer. 2012 Jun 1;118(11):2846-2857. https://doi.org/10.1002/cncr.26598
Rahman, Mohammed Tanjimur ; Nakayama, Kentaro ; Rahman, Munmun ; Nakayama, Naomi ; Ishikawa, Masako ; Katagiri, Atsuko ; Iida, Kouji ; Nakayama, Satoru ; Otsuki, Yoshiro ; Shih, Ie Ming ; Miyazaki, Kohji. / Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma. In: Cancer. 2012 ; Vol. 118, No. 11. pp. 2846-2857.
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