Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: Influence of neuraminidase inhibitors

Miguel Delgado-Rodríguez; Jesús Castilla; Pere Godoy; Vicente Martín; Nuria Soldevila; Jordi Alonso; Jenaro Astray; Maretva Baricot; Rafael Cantón; Ady Castro; Fernando Gónzá Gónzález-Candelas; José María Mayoral; José María Quintana; Tomás Pumarola; Sonia Tamames; Marc Sáez; Angela Domínguez; E. Azor; J. Carrillo; R. Moyano; J. A. Navarro; M. Vázquez; F. Zafra; M. A. Bueno; M. L. Gómez; M. Mariscal; B. Martínez; J. P. Quesada; M. Sillero; M. Carnero; J. Fernández-Crehuet; J. del Diego Salas; V. Fuentes; V. Gallardo; E. Pérez; R. López; J. R. Maldonado; A. Morillo; J. M. Navarro; M. pérez; S. Oña; M. J. Pérez; M. C. Ubago; M. Zarzuela; J. Blanquer; M. Morales; D. Carriedo; F. Díez; I. Fernández; S. Fernandez; M. P. Sanz; J. J. Castrodeza; A. Perez; R. Ortiz de Lejarazu; J. Ortiz; A. Pueyo; J. L. Viejo; P. Redondo; A. Molina; A. Agustí; A. Torres; A. Trilla; A. Vilella; F. Barbé; L. Blanch; G. Navarro; X. Bonfill; J. López-Contreras; V. Pomar; M. T. Puig; E. Borràs; A. Martínez; N. Torner; C. Bravo; F. Moraga; F. Calafell; J. Caylà; C. Tortajada; I. Garcia; J. Ruiz; J. J. García; O. Garín; J. Gea; J. P. Horcajada; N. Hayes; A. Rosell; C. Álvarez; M. Enríquez; F. Pozo; F. Baquero; J. C. Galán; A. Robustillo; M. Valdeón; E. Córdoba; F. Dominguez; J. García; R. Génova; Elisa Gil; S. Jiménez; M. A. Lopaz; J. López; F. Martín; M. L. Martínez; M. Ordobás; E. Rodriguez; S. Sánchez; C. Valdés; J. R. Paño; M. Romero; A. Martinez; L. Martínez; M. Ruiz; P. Fanlo; F. Gil; V. Martínez-Artola; M. E. Ursua; M. Sota; M. T. Virto; J. Gamboa; F. Pérez-Afonso; U. Aguirre; A. Caspelastegui; P. P. España; S. García; J. M. Antoñana; I. Astigarraga; J. I. Pijoan; I. Pocheville; M. Santiago; J. I. Villate; J. Arístegui; A. Escobar; M. I. Garrote; A. Bilbao; C. Garaizar; G. Cilla; J. Korta; E. Pérez Trallero; C. Sarasqueta; F. Esteban; C. Salado; J. L. Lobo; J. Alustizac

doi:10.1093/jac/dks098

Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: Influence of neuraminidase inhibitors

Miguel Delgado-Rodríguez, Jesús Castilla, Pere Godoy, Vicente Martín, Nuria Soldevila, Jordi Alonso, Jenaro Astray, Maretva Baricot, Rafael Cantón, Ady Castro, Fernando Gónzá Gónzález-Candelas, José María Mayoral, José María Quintana, Tomás Pumarola, Sonia Tamames, Marc Sáez, Angela Domínguez, E. Azor, J. Carrillo, R. MoyanoJ. A. Navarro, M. Vázquez, F. Zafra, M. A. Bueno, M. L. Gómez, M. Mariscal, B. Martínez, J. P. Quesada, M. Sillero, M. Carnero, J. Fernández-Crehuet, J. del Diego Salas, V. Fuentes, V. Gallardo, E. Pérez, R. López, J. R. Maldonado, A. Morillo, J. M. Navarro, M. pérez, S. Oña, M. J. Pérez, M. C. Ubago, M. Zarzuela, J. Blanquer, M. Morales, D. Carriedo, F. Díez, I. Fernández, S. Fernandez, M. P. Sanz, J. J. Castrodeza, A. Perez, R. Ortiz de Lejarazu, J. Ortiz, A. Pueyo, J. L. Viejo, P. Redondo, A. Molina, A. Agustí, A. Torres, A. Trilla, A. Vilella, F. Barbé, L. Blanch, G. Navarro, X. Bonfill, J. López-Contreras, V. Pomar, M. T. Puig, E. Borràs, A. Martínez, N. Torner, C. Bravo, F. Moraga, F. Calafell, J. Caylà, C. Tortajada, I. Garcia, J. Ruiz, J. J. García, O. Garín, J. Gea, J. P. Horcajada, N. Hayes, A. Rosell, C. Álvarez, M. Enríquez, F. Pozo, F. Baquero, J. C. Galán, A. Robustillo, M. Valdeón, E. Córdoba, F. Dominguez, J. García, R. Génova, Elisa Gil, S. Jiménez, M. A. Lopaz, J. López, F. Martín, M. L. Martínez, M. Ordobás, E. Rodriguez, S. Sánchez, C. Valdés, J. R. Paño, M. Romero, A. Martinez, L. Martínez, M. Ruiz, P. Fanlo, F. Gil, V. Martínez-Artola, M. E. Ursua, M. Sota, M. T. Virto, J. Gamboa, F. Pérez-Afonso, U. Aguirre, A. Caspelastegui, P. P. España, S. García, J. M. Antoñana, I. Astigarraga, J. I. Pijoan, I. Pocheville, M. Santiago, J. I. Villate, J. Arístegui, A. Escobar, M. I. Garrote, A. Bilbao, C. Garaizar, G. Cilla, J. Korta, E. Pérez Trallero, C. Sarasqueta, F. Esteban, C. Salado, J. L. Lobo, J. Alustizac

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.21, 95% CI=1.21-4.02), corticosteroid therapy (OR=3.37, 95% CI=1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.68, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI=0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI=4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.

Original language	English (US)
Pages (from-to)	1739-1745
Number of pages	7
Journal	Journal of Antimicrobial Chemotherapy
Volume	67
Issue number	7
DOIs	https://doi.org/10.1093/jac/dks098
State	Published - Jul 2012
Externally published	Yes

Keywords

Adverse outcomes
Flu
Length of stay
Pandemic
Prevention

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

Access to Document

10.1093/jac/dks098

Cite this

Delgado-Rodríguez, M., Castilla, J., Godoy, P., Martín, V., Soldevila, N., Alonso, J., Astray, J., Baricot, M., Cantón, R., Castro, A., Gónzález-Candelas, F. G., Mayoral, J. M., Quintana, J. M., Pumarola, T., Tamames, S., Sáez, M., Domínguez, A., Azor, E., Carrillo, J., ... Alustizac, J. (2012). Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: Influence of neuraminidase inhibitors. Journal of Antimicrobial Chemotherapy, 67(7), 1739-1745. https://doi.org/10.1093/jac/dks098

Delgado-Rodríguez, M, Castilla, J, Godoy, P, Martín, V, Soldevila, N, Alonso, J, Astray, J, Baricot, M, Cantón, R, Castro, A, Gónzález-Candelas, FG, Mayoral, JM, Quintana, JM, Pumarola, T, Tamames, S, Sáez, M, Domínguez, A, Azor, E, Carrillo, J, Moyano, R, Navarro, JA, Vázquez, M, Zafra, F, Bueno, MA, Gómez, ML, Mariscal, M, Martínez, B, Quesada, JP, Sillero, M, Carnero, M, Fernández-Crehuet, J, Salas, JDD, Fuentes, V, Gallardo, V, Pérez, E, López, R, Maldonado, JR, Morillo, A, Navarro, JM, pérez, M, Oña, S, Pérez, MJ, Ubago, MC, Zarzuela, M, Blanquer, J, Morales, M, Carriedo, D, Díez, F, Fernández, I, Fernandez, S, Sanz, MP, Castrodeza, JJ, Perez, A, de Lejarazu, RO, Ortiz, J, Pueyo, A, Viejo, JL, Redondo, P, Molina, A, Agustí, A, Torres, A, Trilla, A, Vilella, A, Barbé, F, Blanch, L, Navarro, G, Bonfill, X, López-Contreras, J, Pomar, V, Puig, MT, Borràs, E, Martínez, A, Torner, N, Bravo, C, Moraga, F, Calafell, F, Caylà, J, Tortajada, C, Garcia, I, Ruiz, J, García, JJ, Garín, O, Gea, J, Horcajada, JP, Hayes, N, Rosell, A, Álvarez, C, Enríquez, M, Pozo, F, Baquero, F, Galán, JC, Robustillo, A, Valdeón, M, Córdoba, E, Dominguez, F, García, J, Génova, R, Gil, E, Jiménez, S, Lopaz, MA, López, J, Martín, F, Martínez, ML, Ordobás, M, Rodriguez, E, Sánchez, S, Valdés, C, Paño, JR, Romero, M, Martinez, A, Martínez, L, Ruiz, M, Fanlo, P, Gil, F, Martínez-Artola, V, Ursua, ME, Sota, M, Virto, MT, Gamboa, J, Pérez-Afonso, F, Aguirre, U, Caspelastegui, A, España, PP, García, S, Antoñana, JM, Astigarraga, I, Pijoan, JI, Pocheville, I, Santiago, M, Villate, JI, Arístegui, J, Escobar, A, Garrote, MI, Bilbao, A, Garaizar, C, Cilla, G, Korta, J, Pérez Trallero, E, Sarasqueta, C, Esteban, F, Salado, C, Lobo, JL & Alustizac, J 2012, 'Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: Influence of neuraminidase inhibitors', Journal of Antimicrobial Chemotherapy, vol. 67, no. 7, pp. 1739-1745. https://doi.org/10.1093/jac/dks098

@article{9b0ded3b8d8b40db9c50333ddcb19cc1,

title = "Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: Influence of neuraminidase inhibitors",

abstract = "Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.21, 95% CI=1.21-4.02), corticosteroid therapy (OR=3.37, 95% CI=1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.68, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI=0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI=4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.",

keywords = "Adverse outcomes, Flu, Length of stay, Pandemic, Prevention",

author = "Miguel Delgado-Rodr{\'i}guez and Jes{\'u}s Castilla and Pere Godoy and Vicente Mart{\'i}n and Nuria Soldevila and Jordi Alonso and Jenaro Astray and Maretva Baricot and Rafael Cant{\'o}n and Ady Castro and G{\'o}nz{\'a}lez-Candelas, {Fernando G{\'o}nz{\'a}} and Mayoral, {Jos{\'e} Mar{\'i}a} and Quintana, {Jos{\'e} Mar{\'i}a} and Tom{\'a}s Pumarola and Sonia Tamames and Marc S{\'a}ez and Angela Dom{\'i}nguez and E. Azor and J. Carrillo and R. Moyano and Navarro, {J. A.} and M. V{\'a}zquez and F. Zafra and Bueno, {M. A.} and G{\'o}mez, {M. L.} and M. Mariscal and B. Mart{\'i}nez and Quesada, {J. P.} and M. Sillero and M. Carnero and J. Fern{\'a}ndez-Crehuet and Salas, {J. del Diego} and V. Fuentes and V. Gallardo and E. P{\'e}rez and R. L{\'o}pez and Maldonado, {J. R.} and A. Morillo and Navarro, {J. M.} and M. p{\'e}rez and S. O{\~n}a and P{\'e}rez, {M. J.} and Ubago, {M. C.} and M. Zarzuela and J. Blanquer and M. Morales and D. Carriedo and F. D{\'i}ez and I. Fern{\'a}ndez and S. Fernandez and Sanz, {M. P.} and Castrodeza, {J. J.} and A. Perez and {de Lejarazu}, {R. Ortiz} and J. Ortiz and A. Pueyo and Viejo, {J. L.} and P. Redondo and A. Molina and A. Agust{\'i} and A. Torres and A. Trilla and A. Vilella and F. Barb{\'e} and L. Blanch and G. Navarro and X. Bonfill and J. L{\'o}pez-Contreras and V. Pomar and Puig, {M. T.} and E. Borr{\`a}s and A. Mart{\'i}nez and N. Torner and C. Bravo and F. Moraga and F. Calafell and J. Cayl{\`a} and C. Tortajada and I. Garcia and J. Ruiz and Garc{\'i}a, {J. J.} and O. Gar{\'i}n and J. Gea and Horcajada, {J. P.} and N. Hayes and A. Rosell and C. {\'A}lvarez and M. Enr{\'i}quez and F. Pozo and F. Baquero and Gal{\'a}n, {J. C.} and A. Robustillo and M. Valde{\'o}n and E. C{\'o}rdoba and F. Dominguez and J. Garc{\'i}a and R. G{\'e}nova and Elisa Gil and S. Jim{\'e}nez and Lopaz, {M. A.} and J. L{\'o}pez and F. Mart{\'i}n and Mart{\'i}nez, {M. L.} and M. Ordob{\'a}s and E. Rodriguez and S. S{\'a}nchez and C. Vald{\'e}s and Pa{\~n}o, {J. R.} and M. Romero and A. Martinez and L. Mart{\'i}nez and M. Ruiz and P. Fanlo and F. Gil and V. Mart{\'i}nez-Artola and Ursua, {M. E.} and M. Sota and Virto, {M. T.} and J. Gamboa and F. P{\'e}rez-Afonso and U. Aguirre and A. Caspelastegui and Espa{\~n}a, {P. P.} and S. Garc{\'i}a and Anto{\~n}ana, {J. M.} and I. Astigarraga and Pijoan, {J. I.} and I. Pocheville and M. Santiago and Villate, {J. I.} and J. Ar{\'i}stegui and A. Escobar and Garrote, {M. I.} and A. Bilbao and C. Garaizar and G. Cilla and J. Korta and {P{\'e}rez Trallero}, E. and C. Sarasqueta and F. Esteban and C. Salado and Lobo, {J. L.} and J. Alustizac",

note = "Funding Information: This work was supported by the Ministerio de Ciencia e Innovaci{\'o}n, Insti-tuto de Salud Carlos III (Ministry of Science and Innovation, National Institute of Health Carlos III), Programme of Research on Influenza A/H1N1 (GR09/0030) and Agency for the Management of Grants for University Research (AGAUR, 2009/SGR 42). The funders had no role in the study design, data collection, analysis, the decision to publish or the preparation of the manuscript.",

year = "2012",

month = jul,

doi = "10.1093/jac/dks098",

language = "English (US)",

volume = "67",

pages = "1739--1745",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain

T2 - Influence of neuraminidase inhibitors

AU - Delgado-Rodríguez, Miguel

AU - Castilla, Jesús

AU - Godoy, Pere

AU - Martín, Vicente

AU - Soldevila, Nuria

AU - Alonso, Jordi

AU - Astray, Jenaro

AU - Baricot, Maretva

AU - Cantón, Rafael

AU - Castro, Ady

AU - Gónzález-Candelas, Fernando Gónzá

AU - Mayoral, José María

AU - Quintana, José María

AU - Pumarola, Tomás

AU - Tamames, Sonia

AU - Sáez, Marc

AU - Domínguez, Angela

AU - Azor, E.

AU - Carrillo, J.

AU - Moyano, R.

AU - Navarro, J. A.

AU - Vázquez, M.

AU - Zafra, F.

AU - Bueno, M. A.

AU - Gómez, M. L.

AU - Mariscal, M.

AU - Martínez, B.

AU - Quesada, J. P.

AU - Sillero, M.

AU - Carnero, M.

AU - Fernández-Crehuet, J.

AU - Salas, J. del Diego

AU - Fuentes, V.

AU - Gallardo, V.

AU - Pérez, E.

AU - López, R.

AU - Maldonado, J. R.

AU - Morillo, A.

AU - Navarro, J. M.

AU - pérez, M.

AU - Oña, S.

AU - Pérez, M. J.

AU - Ubago, M. C.

AU - Zarzuela, M.

AU - Blanquer, J.

AU - Morales, M.

AU - Carriedo, D.

AU - Díez, F.

AU - Fernández, I.

AU - Fernandez, S.

AU - Sanz, M. P.

AU - Castrodeza, J. J.

AU - Perez, A.

AU - de Lejarazu, R. Ortiz

AU - Ortiz, J.

AU - Pueyo, A.

AU - Viejo, J. L.

AU - Redondo, P.

AU - Molina, A.

AU - Agustí, A.

AU - Torres, A.

AU - Trilla, A.

AU - Vilella, A.

AU - Barbé, F.

AU - Blanch, L.

AU - Navarro, G.

AU - Bonfill, X.

AU - López-Contreras, J.

AU - Pomar, V.

AU - Puig, M. T.

AU - Borràs, E.

AU - Martínez, A.

AU - Torner, N.

AU - Bravo, C.

AU - Moraga, F.

AU - Calafell, F.

AU - Caylà, J.

AU - Tortajada, C.

AU - Garcia, I.

AU - Ruiz, J.

AU - García, J. J.

AU - Garín, O.

AU - Gea, J.

AU - Horcajada, J. P.

AU - Hayes, N.

AU - Rosell, A.

AU - Álvarez, C.

AU - Enríquez, M.

AU - Pozo, F.

AU - Baquero, F.

AU - Galán, J. C.

AU - Robustillo, A.

AU - Valdeón, M.

AU - Córdoba, E.

AU - Dominguez, F.

AU - García, J.

AU - Génova, R.

AU - Gil, Elisa

AU - Jiménez, S.

AU - Lopaz, M. A.

AU - López, J.

AU - Martín, F.

AU - Martínez, M. L.

AU - Ordobás, M.

AU - Rodriguez, E.

AU - Sánchez, S.

AU - Valdés, C.

AU - Paño, J. R.

AU - Romero, M.

AU - Martinez, A.

AU - Martínez, L.

AU - Ruiz, M.

AU - Fanlo, P.

AU - Gil, F.

AU - Martínez-Artola, V.

AU - Ursua, M. E.

AU - Sota, M.

AU - Virto, M. T.

AU - Gamboa, J.

AU - Pérez-Afonso, F.

AU - Aguirre, U.

AU - Caspelastegui, A.

AU - España, P. P.

AU - García, S.

AU - Antoñana, J. M.

AU - Astigarraga, I.

AU - Pijoan, J. I.

AU - Pocheville, I.

AU - Santiago, M.

AU - Villate, J. I.

AU - Arístegui, J.

AU - Escobar, A.

AU - Garrote, M. I.

AU - Bilbao, A.

AU - Garaizar, C.

AU - Cilla, G.

AU - Korta, J.

AU - Pérez Trallero, E.

AU - Sarasqueta, C.

AU - Esteban, F.

AU - Salado, C.

AU - Lobo, J. L.

AU - Alustizac, J.

N1 - Funding Information: This work was supported by the Ministerio de Ciencia e Innovación, Insti-tuto de Salud Carlos III (Ministry of Science and Innovation, National Institute of Health Carlos III), Programme of Research on Influenza A/H1N1 (GR09/0030) and Agency for the Management of Grants for University Research (AGAUR, 2009/SGR 42). The funders had no role in the study design, data collection, analysis, the decision to publish or the preparation of the manuscript.

PY - 2012/7

Y1 - 2012/7

N2 - Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.21, 95% CI=1.21-4.02), corticosteroid therapy (OR=3.37, 95% CI=1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.68, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI=0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI=4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.

AB - Background: The H1N1 influenza pandemic strain has been associated with a poor prognosis in hospitalized patients. The present report evaluates the factors influencing prognosis. Methods: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. Data on treatment and complications during hospital stay were recorded. As definition of poor outcome, the endpoints of death and admission to intensive care were combined; and as a further outcome, length of stay was used. Results: The mean age was 38.5 years (SD 22.8 years). There were 10 deaths and 79 admissions to intensive care (combined, 88). The use of neuraminidase inhibitors was reported by 495 patients (60.9%). The variables significantly associated with a poor outcome were diabetes (OR=2.21, 95% CI=1.21-4.02), corticosteroid therapy (OR=3.37, 95% CI=1.39-8.20) and use of histamine-2 receptor antagonists (OR=2.68, 95% CI=1.14-6.36), while the use of neuraminidase inhibitors (OR=0.57, 95% CI=0.34-0.94) was protective. Neuraminidase inhibitors within the first 2 days after the influenza onset reduced hospital stay by a mean of 1.9 days (95% CI=4.7-6.6). Conclusions: The use of neuraminidase inhibitors decreases the length of hospital stay and admission to intensive care and/or death.

KW - Adverse outcomes

KW - Flu

KW - Length of stay

KW - Pandemic

KW - Prevention

UR - http://www.scopus.com/inward/record.url?scp=84862703808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862703808&partnerID=8YFLogxK

U2 - 10.1093/jac/dks098

DO - 10.1093/jac/dks098

M3 - Article

C2 - 22467633

AN - SCOPUS:84862703808

SN - 0305-7453

VL - 67

SP - 1739

EP - 1745

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 7

ER -

Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: Influence of neuraminidase inhibitors

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