Profile of bone marrow examination in HIV/AIDS patients to detect opportunistic infections, especially tuberculosis

Medha Khandekar, S. D. Deshmukh, V. V. Holla, S. R. Rane, A. L. Kakrani, S. A. Sangale, A. A. Habbu, D. P. Pandit, A. V. Bhore, Jayagauri Sastry, M. A. Phadke, R. C. Bollinger

Research output: Contribution to journalArticlepeer-review


Morphological evaluation of 140 bone marrow aspirations received in haematopathology laboratory with serologically established HIV infection, along with other relevant special haematological tests, was done during 1st Jan 1999 - 31st Dec 2002 at state government run tertiary care General Hospital in Maharashtra state, India. Out of 140 cases: 118 (84.28%) patients had anaemia, 25 (17.86%) had leukopenia, while 13 (9.28%) were thrombocytopenic. Dyserythropoiesis was present in 18 (12.86%) cases, dysmyelopoiesis 37 (26.43%) and micromegakaryocytes were noted in 44 (31.43%) cases. Haemophagocytosis was evident in 8 (5.71%) cases. Plasmacytosis encountered in 120 (85.71%) cases was a common feature. Based on clinical profile and results of other investigations 56 (40%) patients were clinically diagnosed to be of Mycobacterium tuberculosis (TB). Of these, 18 (12.86%) bone marrow aspirates were positive for AFB, Mycobacterium tuberculosis. In 4 cases cryptococci were demonstrated (Mucicarmine stain). There was one case each of Histoplasma capsulatum and leishmaniasis. One patient showed dense parasitemia with Plasmodium falciparum. One patient had immunoblastic lymphoma and showed bone marrow infiltration. Findings in this study strongly indicate that in HIV/AIDS, AFB stain should be done on each marrow aspirate to rule out tuberculosis in countries like India; where TB and AIDS are marching together.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalIndian Journal of Pathology and Microbiology
Issue number1
StatePublished - Jan 1 2005


  • Bone marrow examination
  • Opportunistic infections
  • Tuberculosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)


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