Products of vasopressin gene expression in small-cell carcinoma of the lung

A. S. Friedmann, K. A. Malott, V. A. Memoli, S. I. Pai, X. M. Yu, W. G. North

Research output: Contribution to journalArticle

Abstract

Small-cell neuroendocrine carcinoma of the lung is known to express products related to the vasopressin gene, although these products have been reported to sometimes differ from those generated by neurones of the hypothalamo-neurohypophyseal system. To further investigate vasopressin gene expression in neuroendocrine carcinomas, we performed immunohistochemistry on 24 histologically classified small-cell carcinomas using antibodies directed against different regions of the vasopressin precursor. All of the tumours examined contained at least two parts of the vasopressin precursor, suggesting that vasopressin might have a biological role in these tumours and indicating a role for these products in tumour diagnosis and treatment. Sixty-seven per cent of the tumours contained immunoreactivity for all major regions of the precursor: vasopressin, vasopressin-associated human neurophysin, the bridging region between the hormone and the neurophysin, and vasopressin-associated human glycopeptide. However, 33% of the tumours examined appeared to express only part of the vasopressin precursor, as evidenced by the absence of immunoreactivity for the neurophysin and/or the glycopeptide. These results support the proposition that both normal and abnormal vasopressin gene expression occurs in small-cell carcinoma of the lung.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalBritish Journal of Cancer
Volume69
Issue number2
StatePublished - Feb 1994
Externally publishedYes

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Small Cell Lung Carcinoma
Vasopressins
Gene Expression
Neurophysins
Neuroendocrine Carcinoma
Small Cell Carcinoma
Glycopeptides
Neoplasms
Immunohistochemistry
Hormones
Neurons
Lung
Antibodies
Genes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Friedmann, A. S., Malott, K. A., Memoli, V. A., Pai, S. I., Yu, X. M., & North, W. G. (1994). Products of vasopressin gene expression in small-cell carcinoma of the lung. British Journal of Cancer, 69(2), 260-263.

Products of vasopressin gene expression in small-cell carcinoma of the lung. / Friedmann, A. S.; Malott, K. A.; Memoli, V. A.; Pai, S. I.; Yu, X. M.; North, W. G.

In: British Journal of Cancer, Vol. 69, No. 2, 02.1994, p. 260-263.

Research output: Contribution to journalArticle

Friedmann, AS, Malott, KA, Memoli, VA, Pai, SI, Yu, XM & North, WG 1994, 'Products of vasopressin gene expression in small-cell carcinoma of the lung', British Journal of Cancer, vol. 69, no. 2, pp. 260-263.
Friedmann AS, Malott KA, Memoli VA, Pai SI, Yu XM, North WG. Products of vasopressin gene expression in small-cell carcinoma of the lung. British Journal of Cancer. 1994 Feb;69(2):260-263.
Friedmann, A. S. ; Malott, K. A. ; Memoli, V. A. ; Pai, S. I. ; Yu, X. M. ; North, W. G. / Products of vasopressin gene expression in small-cell carcinoma of the lung. In: British Journal of Cancer. 1994 ; Vol. 69, No. 2. pp. 260-263.
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