Production of no carrier added 80mBr for investigation of Auger electron toxicity

Ronnie C. Mease, Onofre T. DeJesus, S. John Gatley, Paul V. Harper, Eugene R. Desombre, Arnold M. Friedman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

80mBr (half-life = 4.43 h) is an Auger electron emitting nuclide with convenient properties for investigating Auger electron cytotoxicity and with potential for labeling in vivo radiotherapeutic agents. We have investigated three cyclotron target systems capable of generating 80mBr of sufficiently high specific radioactivity (no carrier added) for biomedical experiments. A 83Kr gas target irradiated with 21.5 MeV deuterons made 80mBr at a production yield of 1.6 ± 0.2 mCi/μAh at saturation. A five-fold increase in 80mBr yield was obtained from 15 MeV proton irradiation of thin elemental Se enriched in 80Se targets although technical improvements are expected to further raise this production yield. This route is therefore superior for current medical cyclotrons. Irradiation of a reusable 80Se copper selenide target also yielded multi-millicurie amounts of 80mBr, and recovery of radiobromine by dry distillation is faster and more convenient than in the elemental Se target, but an optimum copper selenide target for 80mBr production has not yet been built.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume42
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

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