Production of atypical measles in rhesus macaques: Evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody

Fernando P. Polack, Paul G Auwaerter, Sok H. Lee, Hossein C. Nousari, Alexandra Valsamakis, Kristin M. Leiferman, Arwind Diwan, Robert John Adams, Diane Griffin

Research output: Contribution to journalArticle

Abstract

The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and fusion-inhibiting antibodies, but no cytotoxic T- cell response. Subsequent infection with measles virus caused an atypical rash and pneumonitis, accompanied by immune complex deposition and an increase in eosinophils. Fusion-inhibiting antibody appeared earlier in these monkeys than in non-immunized monkeys. These data indicate that atypical measles results from previous priming for a nonprotective type 2 CD4 T-cell response rather than from lack of functional antibody against the fusion protein.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalNature Medicine
Volume5
Issue number6
DOIs
StatePublished - Jun 1999

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Immune Complex Diseases
Measles
Antigen-Antibody Complex
Macaca mulatta
Eosinophils
Fusion reactions
Inactivated Vaccines
T-cells
Antibodies
Haplorhini
Measles Vaccine
T-Lymphocytes
Measles virus
Exanthema
Viruses
Formaldehyde
Pneumonia
Infection
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Production of atypical measles in rhesus macaques : Evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody. / Polack, Fernando P.; Auwaerter, Paul G; Lee, Sok H.; Nousari, Hossein C.; Valsamakis, Alexandra; Leiferman, Kristin M.; Diwan, Arwind; Adams, Robert John; Griffin, Diane.

In: Nature Medicine, Vol. 5, No. 6, 06.1999, p. 629-634.

Research output: Contribution to journalArticle

Polack, Fernando P. ; Auwaerter, Paul G ; Lee, Sok H. ; Nousari, Hossein C. ; Valsamakis, Alexandra ; Leiferman, Kristin M. ; Diwan, Arwind ; Adams, Robert John ; Griffin, Diane. / Production of atypical measles in rhesus macaques : Evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody. In: Nature Medicine. 1999 ; Vol. 5, No. 6. pp. 629-634.
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