Production of atypical measles in rhesus macaques: Evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody

Fernando P. Polack, Paul G. Auwaerter, Sok H. Lee, Hossein C. Nousari, Alexandra Valsamakis, Kristin M. Leiferman, Arwind Diwan, Robert J. Adams, Diane E. Griffin

Research output: Contribution to journalArticlepeer-review

Abstract

The severe disease atypical measles occurred when individuals immunized with a poorly protective inactivated vaccine contracted measles, and was postulated to be due to a lack of fusion-inhibiting antibodies. Here, rhesus macaques immunized with formalin-inactivated measles vaccine developed transient neutralizing and fusion-inhibiting antibodies, but no cytotoxic T- cell response. Subsequent infection with measles virus caused an atypical rash and pneumonitis, accompanied by immune complex deposition and an increase in eosinophils. Fusion-inhibiting antibody appeared earlier in these monkeys than in non-immunized monkeys. These data indicate that atypical measles results from previous priming for a nonprotective type 2 CD4 T-cell response rather than from lack of functional antibody against the fusion protein.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalNature medicine
Volume5
Issue number6
DOIs
StatePublished - Jun 1 1999

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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