Procollagens as markers for the cell of origin of human bone tumors

Robert Stern, Joseph Wilczek, William P. Thorpe, Steven A. Rosenberg

Research output: Contribution to journalArticlepeer-review


Cells derived from osteogenic sarcomas and from Ewing's sarcomas, two malignant bone tumors, were examined for the types of collagens they elaborated into the tissue culture media. Type I procollagen was the predominant species from all osteogenic sarcoma cell lines, a finding consistent with bone cell origin. The Ewing's sarcoma cells contained a prominent peak of type III procollagen and resembled the profile of vascular smooth muscle cells. Fibroblasts derived from skin biopsies taken from amputation specimens synthesized both type I and type III procollagens at the expected ratio of approximately 3: 1. The examination of matrix proteins may provide a general classification scheme for human sarcomas and permit distinction of one tumor from another, as well as from normal fibroblasts.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalCancer Research
Issue number2
StatePublished - Feb 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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