Procarcinogenic regulatory T cells in microbial-induced colon cancer

Abby L. Geis; Franck Housseau

doi:10.1080/2162402X.2015.1118601

Procarcinogenic regulatory T cells in microbial-induced colon cancer

Abby L. Geis, Franck Housseau

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

Original language	English (US)
Journal	OncoImmunology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1080/2162402X.2015.1118601
State	Published - Apr 2 2016

Keywords

Carcinogenesis
Enterotoxigenic Bacteroides fragilis
IL-17
Inflammation
Microbiome

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2015.1118601

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title = "Procarcinogenic regulatory T cells in microbial-induced colon cancer",

abstract = "ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.",

keywords = "Carcinogenesis, Enterotoxigenic Bacteroides fragilis, IL-17, Inflammation, Microbiome",

author = "Geis, {Abby L.} and Franck Housseau",

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AU - Geis, Abby L.

AU - Housseau, Franck

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N2 - ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

AB - ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

KW - Carcinogenesis

KW - Enterotoxigenic Bacteroides fragilis

KW - IL-17

KW - Inflammation

KW - Microbiome

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Procarcinogenic regulatory T cells in microbial-induced colon cancer

Abstract

Keywords

ASJC Scopus subject areas

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