Procarcinogenic regulatory T cells in microbial-induced colon cancer

Abby L. Geis, Franck Housseau

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT: Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

Original languageEnglish (US)
JournalOncoImmunology
Volume5
Issue number4
DOIs
StatePublished - Apr 2 2016

Keywords

  • Carcinogenesis
  • Enterotoxigenic Bacteroides fragilis
  • IL-17
  • Inflammation
  • Microbiome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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