Problems with Lithium as Treatment for Inappropriate A.D.H Secretion

Nelson Hendler, Sumio Uematsu, Donlin M. Long, George Allen

Research output: Contribution to journalLetter


To the Editor: A recent article by Drs. De Troyer and Demanet (N Engl J Med 293:915, 1975) reported the successful long-term treatment of the syndrome of inappropriate secretion of antidiuretic hormone, with use of demeclocycline, instead of lithium, which had been reported earlier in the Journal,1thereby avoiding the side effects of lithium. There are other reasons to abstain from lithium use in this syndrome. The earlier article1suggested that during short-term (48 hours) lithium administration for the treatment of inappropriate secretion of antidiuretic hormone, sodium “retention was secondary to the effect of increased aldosterone.” The assumption. . . No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number8
StatePublished - Feb 19 1976

ASJC Scopus subject areas

  • Medicine(all)

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