Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

Bjoern Neumann; Sarah Foerster; Chao Zhao; Benedetta Bodini; Daniel S. Reich; Dwight E. Bergles; Ragnhildur Thóra Káradóttir; Catherine Lubetzki; Luke L. Lairson; Bernard Zalc; Bruno Stankoff; Robin J.M. Franklin

doi:10.1016/j.stem.2020.03.017

Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

Bjoern Neumann, Sarah Foerster, Chao Zhao, Benedetta Bodini, Daniel S. Reich, Dwight E. Bergles, Ragnhildur Thóra Káradóttir, Catherine Lubetzki, Luke L. Lairson, Bernard Zalc, Bruno Stankoff, Robin J.M. Franklin

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

7 Scopus citations

Abstract

Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

Original language	English (US)
Pages (from-to)	617-619
Number of pages	3
Journal	Cell stem cell
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.stem.2020.03.017
State	Published - May 7 2020

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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title = "Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis",

abstract = "Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.",

author = "Bjoern Neumann and Sarah Foerster and Chao Zhao and Benedetta Bodini and Reich, {Daniel S.} and Bergles, {Dwight E.} and K{\'a}rad{\'o}ttir, {Ragnhildur Th{\'o}ra} and Catherine Lubetzki and Lairson, {Luke L.} and Bernard Zalc and Bruno Stankoff and Franklin, {Robin J.M.}",

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year = "2020",

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T1 - Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

AU - Neumann, Bjoern

AU - Foerster, Sarah

AU - Zhao, Chao

AU - Bodini, Benedetta

AU - Reich, Daniel S.

AU - Bergles, Dwight E.

AU - Káradóttir, Ragnhildur Thóra

AU - Lubetzki, Catherine

AU - Lairson, Luke L.

AU - Zalc, Bernard

AU - Stankoff, Bruno

AU - Franklin, Robin J.M.

PY - 2020/5/7

Y1 - 2020/5/7

N2 - Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

AB - Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.

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U2 - 10.1016/j.stem.2020.03.017

DO - 10.1016/j.stem.2020.03.017

M3 - Comment/debate

C2 - 32386552

AN - SCOPUS:85084118366

SN - 1934-5909

VL - 26

SP - 617

EP - 619

JO - Cell stem cell

JF - Cell stem cell

IS - 5

ER -

Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

Abstract

ASJC Scopus subject areas

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