Probing the topography of kainate recognition sites: Synthesis of a novel oxetane containing kainic acid analogue.

Alan P. Kozikowski, Abdul H. Fauq

Research output: Contribution to journalArticlepeer-review

Abstract

A short synthesis of the conformationally rigidified spirocyclic-kainic acid analogue 2 is described starting from kainic acid. This relatively conservative change in the structure of kainic acid has been found to lead to a loss of affinity for glutamate recognition sites.

Original languageEnglish (US)
Pages (from-to)2967-2970
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number21
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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