Probing the topography of kainate recognition sites: Synthesis of a novel oxetane containing kainic acid analogue.

Alan P. Kozikowski; Abdul H. Fauq

doi:10.1016/S0040-4039(00)89000-0

Probing the topography of kainate recognition sites: Synthesis of a novel oxetane containing kainic acid analogue.

Alan P. Kozikowski, Abdul H. Fauq

School of Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A short synthesis of the conformationally rigidified spirocyclic-kainic acid analogue 2 is described starting from kainic acid. This relatively conservative change in the structure of kainic acid has been found to lead to a loss of affinity for glutamate recognition sites.

Original language	English (US)
Pages (from-to)	2967-2970
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)89000-0
State	Published - 1990

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)89000-0

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title = "Probing the topography of kainate recognition sites: Synthesis of a novel oxetane containing kainic acid analogue.",

abstract = "A short synthesis of the conformationally rigidified spirocyclic-kainic acid analogue 2 is described starting from kainic acid. This relatively conservative change in the structure of kainic acid has been found to lead to a loss of affinity for glutamate recognition sites.",

author = "Kozikowski, {Alan P.} and Fauq, {Abdul H.}",

year = "1990",

doi = "10.1016/S0040-4039(00)89000-0",

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volume = "31",

pages = "2967--2970",

journal = "Tetrahedron Letters",

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T2 - Synthesis of a novel oxetane containing kainic acid analogue.

AU - Kozikowski, Alan P.

AU - Fauq, Abdul H.

PY - 1990

Y1 - 1990

N2 - A short synthesis of the conformationally rigidified spirocyclic-kainic acid analogue 2 is described starting from kainic acid. This relatively conservative change in the structure of kainic acid has been found to lead to a loss of affinity for glutamate recognition sites.

AB - A short synthesis of the conformationally rigidified spirocyclic-kainic acid analogue 2 is described starting from kainic acid. This relatively conservative change in the structure of kainic acid has been found to lead to a loss of affinity for glutamate recognition sites.

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U2 - 10.1016/S0040-4039(00)89000-0

DO - 10.1016/S0040-4039(00)89000-0

M3 - Article

AN - SCOPUS:0025360270

SN - 0040-4039

VL - 31

SP - 2967

EP - 2970

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

Probing the topography of kainate recognition sites: Synthesis of a novel oxetane containing kainic acid analogue.

Abstract

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