Probing the D-1,4,5-IP3/D-1,3,4,5-IP4 functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abdul H. Fauq; Alan P. Kozikowski; Vassil I. Ognyanov; Robert A. Wilcox; Stefan R. Nahorski

doi:10.1039/C39940001301

Probing the D-1,4,5-IP₃/D-1,3,4,5-IP₄ functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abdul H. Fauq, Alan P. Kozikowski, Vassil I. Ognyanov, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP₃) in cellular signalling, three novel D-3-substituted analogues of IP₃ have been synthesized; their binding and Ca²⁺-release profiles at the IP₃-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.

Original language	English (US)
Pages (from-to)	1301-1302
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	11
DOIs	https://doi.org/10.1039/C39940001301
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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Probing the D-1,4,5-IP₃/D-1,3,4,5-IP₄ functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues. / Fauq, Abdul H.; Kozikowski, Alan P.; Ognyanov, Vassil I. et al.
In: Journal of the Chemical Society, Chemical Communications, No. 11, 1994, p. 1301-1302.

Research output: Contribution to journal › Article › peer-review

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abstract = "To explore the biological significance of the D-3 position phosphorylation of the second messenger D-myo-inositol 1,4,5-trisphosphate (IP3) in cellular signalling, three novel D-3-substituted analogues of IP3 have been synthesized; their binding and Ca2+-release profiles at the IP3-receptor have been studied and shown to correlate with the steric requirement of the D-3 substituent.",

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AU - Wilcox, Robert A.

AU - Nahorski, Stefan R.

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Probing the D-1,4,5-IP₃/D-1,3,4,5-IP₄ functional interface. Synthesis and pharmacology of novel D-3-modified myo-inositol trisphosphate analogues

Abstract

ASJC Scopus subject areas

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