Probing the actions of endocrine disrupting compounds through genetic approaches in zebrafish

Daniel A. Gorelick, Marnie Halpern

Research output: Contribution to journalArticle

Abstract

Endocrine disrupting compounds (EDCs) are a persistent threat to human and animal health. Detecting these agents and identifying their basic mechanisms of action is crucial to determining their impact. However, defining the differing effects of EDCs and their sites of activity, such as why some tissues are more sensitive than others, is a challenging endeavor. The zebrafish (Danio rerio) is a powerful genetic model that can provide unique insights into these issues. New tools for transgenesis and genome editing are enabling the identification of specific proteins and receptors that mediate the response to EDC exposure. We outline how transgenic reporters that detect EDCs and targeted mutations against their receptors or downstream effectors make zebrafish an especially favorable system for toxicological research.

Original languageEnglish (US)
Article numbere975547
JournalEndocrine Disruptors
Volume2
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • CRISPR
  • Effectdirected analysis
  • Endocrine disrupting compounds
  • Estrogen receptor
  • Genome manipulation
  • Transgenesis
  • Zebrafish

ASJC Scopus subject areas

  • Endocrinology

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