Probenecid impairment of acetaminophen and lorazepam clearance: Direct inhibition of ether glucuronide formation

D. R. Abernethy, D. J. Greenblatt, B. Ameer, R. I. Shader

Research output: Contribution to journalArticle

Abstract

Eleven subjects received acetaminophen (650 mg i.v.) on two occassions in random sequence, with and without concurrent administration of probenecid (500 mg) every 6 hr. Nine subjects similarly received lorazepam (2 mg i.v.) with and without concurrent probenecid. Acetaminophen half-life was prolonged during probenecid treatment (mean ± S.E., 4.30 ± 0.23 vs. 2.51 ± 0.16 hr; P

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume234
Issue number2
StatePublished - 1985
Externally publishedYes

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Lorazepam
Probenecid
Glucuronides
Acetaminophen
Ether
Half-Life

ASJC Scopus subject areas

  • Pharmacology

Cite this

Probenecid impairment of acetaminophen and lorazepam clearance : Direct inhibition of ether glucuronide formation. / Abernethy, D. R.; Greenblatt, D. J.; Ameer, B.; Shader, R. I.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 234, No. 2, 1985, p. 345-349.

Research output: Contribution to journalArticle

Abernethy, D. R. ; Greenblatt, D. J. ; Ameer, B. ; Shader, R. I. / Probenecid impairment of acetaminophen and lorazepam clearance : Direct inhibition of ether glucuronide formation. In: Journal of Pharmacology and Experimental Therapeutics. 1985 ; Vol. 234, No. 2. pp. 345-349.
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