Pro 12Ala of the peroxisome proliferator-activated receptor-γ2 gene is associated with lower serum insulin levels in nonobese African Americans: The atherosclerosis risk in communities study

W. H.Linda Kao, Josef Coresh, Alan R. Shuldiner, Eric Boerwinkle, Molly S. Bray, Frederick L. Brancati

Research output: Contribution to journalArticlepeer-review

Abstract

Recent research suggests that the Pro12Ala variant in peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with diabetes- and obesity-related traits, and that its effects may be modified by obesity status. We characterized this variant in a population-based sample of 1,441 middle-aged African-American individuals with respect to diabetes-, obesity-, and other cardiovascular-related traits, both cross-sectionally and prospectively. The overall frequency of Ala12 was 1.9% (95% CI 1.5-2.5%), significantly lower than in Caucasian populations. Consistent with previous findings in Caucasians, African Americans with type 2 diabetes tended to be less likely to have the Pro/Ala genotype than those without (odds ratio [OR] 0.64, 95% CI 0.34- 1.20); however, this OR was not statistically significant. Among nonobese individuals, the Pro/Ala genotype was associated with significantly lower ln(insulin) (P = 0.001), lower ln(HOMA-IR) (homeostasis model assessment of insulin resistance) (P = 0.002), higher fasting glucose-to-insulin ratio (P = 0.005), and lower diastolic blood pressure (P = 0.02). Among overweight individuals (BMI 25-29.9 kg/m2), the Pro/Ala genotype was associated with greater BMI (P = 0.02), waist-to-hip ratio (P = 0.01), and waist circumference (P = 0.04). Among obese individuals, there was no association between any of the diabetes- or obesity-related traits and the Pro12Ala PPAR-γ2 variant. We conclude that among nonobese African Americans, the Pro/Ala genotype is associated with markers of greater insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)1568-1572
Number of pages5
JournalDiabetes
Volume52
Issue number6
DOIs
StatePublished - Jun 1 2003

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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